ArticleCell stress & chaperones2024
J-domain proteins: From molecular mechanisms to diseases.
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Article in Cell stress & chaperones, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 18 citations in OpenAlex.
- Focus on DnaJ protein research from Arabidopsis to crop improvement.The plant genome · 2026Review
- DNAJB6: A guardian against neurodegeneration.Neural regeneration research · 2026Article
- Stress-specific expression of HSPA and DNAJ chaperones regulated by NRF2/HSF1 in neurodegenerative conditions.Molecular and cellular biochemistry · 2026Article
- The cotranslational cycle of the ribosome-bound Hsp70 homolog Ssb.Nature communications · 2026Article
- Effects of solution conditions on the self-assembly of the chaperone protein DNAJB6b.Communications chemistry · 2025Article
- Hyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice.Communications biology · 2024Article
- Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases.Cell stress & chaperones · 2024Review
- The dance of proteostasis and metabolism: Unveiling the caloristatic controlling switch.Cell stress & chaperones · 2024Review
- Unique characteristics of the J-domain proximal regions of Hsp70 cochaperone Apj1 in prion propagation/elimination and its overlap with Sis1 function.Frontiers in molecular biosciences · 2024Article
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Authors and funding
37 authors at 20 institutions in 17 countries.
Jaroslaw MarszalekIntercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, Gdansk 80-307, Poland.
Paolo De Los RiosInstitute of Physics, School of Basic Sciences, École Polytechnique Fédérale de Lausanne - EPFL, Lausanne CH 1015, Switzerland; Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne - EPFL, Lausanne CH 1015, Switzerland.
Douglas CyrDepartment of Cell Biology and Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Matthias P MayerCenter for Molecular Biology of Heidelberg University (ZMBH), Heidelberg 69120, Germany.
Vasista AdupaZernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands.
Claes AndréassonDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm S-10691, Sweden.
Gregory L BlatchBiomedical Research and Drug Discovery Research Group, Faculty of Health Sciences, Higher Colleges of Technology, Sharjah, United Arab Emirates; The Vice Chancellery, The University of Notre Dame Australia, Fremantle, Western Australia, Australia; Biomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa.
Janice E A BraunHotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Jeffrey L BrodskyDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Bernd BukauCenter for Molecular Biology of Heidelberg University (ZMBH), Heidelberg 69120, Germany.
J Paul ChappleWilliam Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom.
Charlotte ConzInstitute of Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Sébastien DementinAix Marseille Univ, CNRS, BIP UMR 7281, IMM, 31 Chemin Joseph Aiguier, Marseille 13402, France.
Pierre GenevauxLaboratoire de Microbiologie et Génétique Moléculaires (LMGM), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Université Toulouse III - Paul Sabatier (UT3), Toulouse, France.
Olivier GenestAix Marseille Univ, CNRS, BIP UMR 7281, IMM, 31 Chemin Joseph Aiguier, Marseille 13402, France.
Pierre GoloubinoffDepartment of Plant Molecular Biology, Faculty of Biology and Medicine, Lausanne University, Lausanne 1015, Switzerland.
Jason GestwickiDepartment of Pharmaceutical Chemistry and the Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA 94308, USA.
Colin M HammondNovo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Molecular & Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom.
Justin K HinesDepartment of Chemistry, Lafayette College, Easton, PA, USA.
Koji IshikawaCenter for Molecular Biology of Heidelberg University (ZMBH), Heidelberg 69120, Germany.
Lukasz A JoachimiakCenter for Alzheimer's and Neurodegenerative Diseases, UT Southwestern Medical Center, Dallas, TX, USA; Peter O'Donnell Jr Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.
Janine KirsteinLeibniz Institute on Aging - Fritz Lipmann Institute and Institute of Biochemistry and Biophysics, Friedrich Schiller University Jena, Jena 07745, Germany.
Krzysztof LiberekIntercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, Gdansk 80-307, Poland.
Dejana MokranjacLMU Munich, Biocenter-Cell Biology, Großhadernerstr. 2, Planegg-Martinsried 82152, Germany.
Nadinath NillegodaAustralian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia; Centre for Dementia and Brain Repair at the Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia.
Carlos H I RamosInstitute of Chemistry, University of Campinas-UNICAMP, P.O. Box 6154, 13083-970 Campinas, SP, Brazil.
Mathieu RebeaudInstitute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne - EPFL, Lausanne CH 1015, Switzerland.
David RonUniversity of Cambridge, Cambridge CB2 0XY, United Kingdom.
Sabine RospertInstitute of Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Chandan SahiDepartment of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, Bhopal, Madhya Pradesh, India; IISER Bhopal, Room Number 117, AB3, Bhopal Bypass Road, Bhopal 462066, Madhya Pradesh, India.
Reut ShalgiDepartment of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel.
Bartlomiej TomiczekIntercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, Gdansk 80-307, Poland.
Ryo UshiodaDepartment of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto 603-8555, Japan.
Elizaveta UstyantsevaDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Yihong YeNational Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Maciej ZyliczFoundation for Polish Science, Warsaw 02-611, Poland.
Harm H KampingaDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: h.h.kampinga@umcg.nl.
Centre National de la Recherche Scientifique · FRHeidelberg University · DEÉcole Polytechnique Fédérale de Lausanne · CHGdańsk Medical University · PLUniversity Medical Center Groningen · NLUniversity of Freiburg · DEAustralian Regenerative Medicine Institute · AUFoundation for Polish Science · PLHigher Colleges of Technology · AEIndian Institute of Science Education and Research, Bhopal · INKyoto Sangyo University · JPLafayette College · USLeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DENational Institutes of Health · USQueen Mary University of London · GBSouthwestern Medical Center · USStockholm University · SETechnion – Israel Institute of Technology · ILUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Calgary · CA
Funding
Roles for Hsp70 and Hsp40 in Membrane Protein TriageR01GM056981 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CYR, DOUGLAS M · 1998 to 2019
$6.1MHsp40 and Hsp70 in Membrane Protein TriageR01GM151501 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DOUGLAS M CYR · 2023 to 2026
$1.7MNIGMS NIH HHS R01 GM056981NIGMS NIH HHS R01 GM151501
Abstract
J-domain proteins (JDPs) are the largest family of chaperones in most organisms, but much of how they function within the network of other chaperones and protein quality control machineries is still an enigma. Here, we report on the latest findings related to JDP functions presented at a dedicated JDP workshop in Gdansk, Poland. The report does not include all (details) of what was shared and discussed at the meeting, because some of these original data have not yet been accepted for publication elsewhere or represented still preliminary observations at the time.
Indexed as
HSP70 Heat-Shock ProteinsMolecular ChaperonesHSP40 Heat-Shock ProteinsPolandHSP40 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsMolecular ChaperonesEvolutionHsp70 cycleJDP
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.