ArticleNEJM evidence2023
Hypertensive Disorders of Pregnancy and Risk of Stroke in U.S. Black Women.
Article in NEJM evidence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Complications Following Pre-eclampsia.Maternal and child health journal · 2024Pooled it
- Experiences of Racism and Risk of Preeclampsia in the Black Women's Health Study.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Closing the Gap Between Recommendation and Uptake: Provider Communication About Low-Dose Aspirin for Preeclampsia Prevention.Journal of pediatrics, perinatology and child health · 2026Article
- Addressing maternal cardiovascular risk: The impact of lactation, adverse pregnancy outcomes, and racial disparities.American heart journal plus : cardiology research and practice · 2025Article
- Association of a History of Preterm Delivery With Stroke Risk in the Black Women's Health Study.Neurology · 2025Article
- Article
- A Bayesian zero-inflated spatially varying coefficients model for overdispersed binomial data.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2025Article
- Association between Apolipoprotein L1 genetic variants and risk of preeclampsia and preterm birth among U.S. Black women.European journal of obstetrics & gynecology and reproductive biology: X · 2025Article
- Racial and Ethnic Disparities in Stroke Incidence and Outcomes.Current cardiovascular risk reports · 2025Article
- Analysis of ICAM-1 rs3093030, VCAM-1 rs3783605, and E-Selectin rs1805193 Polymorphisms in African Women Living with HIV and Preeclampsia.International journal of molecular sciences · 2024Article
- Trauma and Posttraumatic Stress Disorder as Important Risk Factors for Gestational Metabolic Dysfunction.American journal of perinatology · 2024Review
- Perceived Interpersonal Racism in Relation to Incident Coronary Heart Disease Among Black Women.Circulation · 2024Article
- Perceived Interpersonal Racism and Incident Stroke Among US Black Women.JAMA network open · 2023Article
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9 authors.
Funding
Abstract
backgroundBlack women have a disproportionately higher burden of both preeclamptic pregnancy and stroke compared with White women, but virtually all existing evidence on this possible association has been generated from women of European ancestry.
methodsIn the Black Women’s Health Study, a prospective cohort of U.S. Black women who enrolled in 1995, 42,924 participants were parous and free of cardiovascular disease at baseline. Biennial questionnaires included questions on preeclampsia, gestational hypertension, and stroke. We sought the medical records for participants who reported a stroke, and we reviewed them blinded to reproductive history. Cox proportional-hazards models, with control for potential confounders, were used to estimate hazard ratios and 95% confidence intervals (CIs).
resultsOver a median of 22 years of follow-up, there were 1555 incident strokes, including 310 among 4938 women with a history of hypertensive disorders of pregnancy (HDOP). The multivariable hazard ratio for stroke for women with any HDOP compared with those who had never experienced HDOP was 1.66 (95% CI, 1.46 to 1.89). Comparable hazard ratios were 1.53 (95% CI, 1.29 to 1.82) for preeclampsia and 1.81 (95% CI, 1.53 to 2.13) for gestational hypertension only. Associations were similar among women under age 55 years and those aged 55 years and older.
conclusionsIn this prospective study of Black women, a history of HDOP was associated with an estimated 66% increased long-term risk of stroke. This association may contribute to the disproportionately higher stroke incidence in Black women given the higher prevalence of HDOP in this population. (Funded by the U.S. National Institutes of Health.)
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