Evidence map›Paper›PMID 38319964›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Design of universal Ebola virus vaccine candidates via immunofocusing.

Duo Xu, Abigail E Powell, Ashley Utz, Mrinmoy Sanyal, Jonathan Do, J J Patten, Juan I Moliva, Nancy J Sullivan, Robert A Davey, Peter S Kim

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Review
  6. Article
  7. Article
  8. Article
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  11. Article
  12. Immunofocusing design of a fusion glycoprotein monomer vaccine for respiratory syncytial virus.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Making Universal Vaccines and Antibodies Through Glycoengineering.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Duo XuDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-0483-8719
Abigail E PowellDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.
Ashley UtzSarafan ChEM-H, Stanford University, Stanford, CA 94305.
Mrinmoy SanyalDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-1365-4279
Jonathan DoDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.
J J PattenNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118.ORCID 0000-0002-9770-7525
Juan I MolivaNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118.
Nancy J SullivanNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118.
Robert A DaveyNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118.ORCID 0000-0001-9168-2892
Peter S KimDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0001-6503-4541
Stanford University · USBoston University · USChan Zuckerberg Initiative (United States) · US

Funding

Regulatory Compliance CoreUC7AI095321 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROBERT A DAVEY · 2014 to 2026
$159.3M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007365 · NIGMS · STANFORD UNIVERSITY · PI CHUA, KATRIN F · 1985 to 2021
$33.8M
Medical Scientist Training ProgramT32GM145402 · NIGMS · STANFORD UNIVERSITY · PI Katrin F. Chua · 2022 to 2026
$10.0M
Creating high-resolution, epitope-focused vaccinesDP1AI158125 · NIAID · STANFORD UNIVERSITY · PI KIM, PETER S · 2020 to 2024
$5.9M
NIAID NIH HHS DP1 AI158125NIAID NIH HHS UC7 AI095321NIGMS NIH HHS T32 GM007365NIGMS NIH HHS T32 GM145402
6 · The paper itself

Abstract

The Ebola virus causes hemorrhagic fever in humans and poses a significant threat to global public health. Although two viral vector vaccines have been approved to prevent Ebola virus disease, they are distributed in the limited ring vaccination setting and only indicated for prevention of infection from

Indexed as

Ebola VaccinesEbolavirusHemorrhagic Fever, EbolaViral VaccinesAnimalsAntibodies, NeutralizingAntibodies, ViralHumansImmune SeraMiceAntibodies, NeutralizingAntibodies, ViralEbola VaccinesImmune SeraViral Vaccinescross-neutralizationhyperglycosylationimmunofocusing designuniversal Ebola virus vaccine

Identifiers

PMID38319964
PMCPMC10873634
OpenAlexW4391560186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.