Evidence map›Paper›PMID 38319936›Full record

ArticlePloS one2024

Low serum brain-derived neurotrophic factor may predict poor response to cardiac rehabilitation in patients with cardiovascular disease.

Yuya Tsukada, Yasuhiro Nishiyama, Michiya Kishimoto, Takeshi Nago, Haruhito Harada, Hiroshi Niiyama, Atsushi Katoh, Hiroo Matsuse, Hisashi Kai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yuya TsukadaDivision of Rehabilitation, Kurume University Medical Center, Kurume, Fukuoka, Japan.ORCID 0000-0002-2207-5973
Yasuhiro NishiyamaDepartment of Cardiology, Kurume University Medical Center, Kurume, Fukuoka, Japan.
Michiya KishimotoDivision of Rehabilitation, Kurume University Medical Center, Kurume, Fukuoka, Japan.
Takeshi NagoDivision of Rehabilitation, Kurume University Medical Center, Kurume, Fukuoka, Japan.
Haruhito HaradaDepartment of Cardiology, Kurume University Medical Center, Kurume, Fukuoka, Japan.ORCID 0000-0002-3042-3843
Hiroshi NiiyamaDepartment of Cardiology, Kurume University Medical Center, Kurume, Fukuoka, Japan.
Atsushi KatohDepartment of Cardiology, Kurume University Medical Center, Kurume, Fukuoka, Japan.
Hiroo MatsuseDivision of Rehabilitation, Kurume University Hospital, Kurume, Fukuoka, Japan.
Hisashi KaiDepartment of Cardiology, Kurume University Medical Center, Kurume, Fukuoka, Japan.
Kurume University Medical Center · JPKurume University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt has been shown that serum brain-derived neurotrophic factor (BDNF) is associated with skeletal muscle energy metabolism and that BDNF is a predictor of mortality in heart failure patients. However, little is known about the relationship between BDNF and cardiac rehabilitation (CR). Therefore, this study retrospectively investigated the effects of baseline serum BDNF levels on the CR-induced exercise capacity improvement in patients with cardiovascular disease (CVD).

methodsWe assigned 99 CVD patients (mean age 71±12 years, male = 60) to Low, Middle, and High groups based on the tertiles of baseline BDNF levels. Cardiopulmonary exercise testing was done using supervised bicycle ergometer twice before and after 3 weeks of CR. Analysis of covariance (ANCOVA) followed by post-hoc analysis using Tukey's HSD test was conducted to assess the multivariate associations between baseline BDNF levels categorized by BDNF tertiles (as independent variable) and %increases in AT and peak VO2 after 3-week CR (as dependent variables) after adjustment for age and gender (as covariates), as a main statistical analysis of the present study.

resultsThe higher the baseline BDNF levels, the better nutritional status evaluated by the CONUT score (p<0.0001). Baseline anaerobic threshold (AT) and peak oxygen uptake (peak VO2) were similar among the three groups. ANCOVA followed by post-hoc analysis revealed that age- and gender-adjusted %increases in peak VO2 after 3-week CR were positively associated with baseline BDNF levels (p = 0.0239) and Low BDNF group showed significantly lower %increase in peak VO2 than High BDNF group (p = 0.0197). Significant association was not found between baseline BDNF and %increase in AT (p = 0.1379).

conclusionsLow baseline BDNF levels were associated with malnutrition in CVD patients. A positive association between baseline BDNF levels and CR-induced increases in peak VO2 was found. It was suggested that CVD patients with low baseline BDNF levels may be poor responders to CR.

Indexed as

Cardiac RehabilitationCardiovascular DiseasesAgedAged, 80 and overBrain-Derived Neurotrophic FactorFemaleHumansMaleMiddle AgedOxygen ConsumptionRetrospective StudiesBrain-Derived Neurotrophic Factor

Identifiers

PMID38319936
PMCPMC10846715
OpenAlexW4391560344

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.