Evidence map›Paper›PMID 38319516›Full record

ArticleAnnals of surgical oncology2024

Prognostic Value of Myosteatosis and Creatinine-to-Cystatin C Ratio in Patients with Pancreatic Cancer Who Underwent Radical Surgery.

Shenghua Bi, Yueping Jiang, Ge Guan, Xueguo Sun, Xiaowei Wang, Lingyun Zhang, Xue Jing

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In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shenghua BiGastroenterology Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yueping JiangGastroenterology Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Ge GuanLiver Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Xueguo SunGastroenterology Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Xiaowei WangGastroenterology Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Lingyun ZhangGastroenterology Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Xue JingGastroenterology Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. jingxue@qdu.edu.cn.

Funding

the National Natural Science Foundation of Shandong Province ZR202103040311
6 · The paper itself

Abstract

backgroundMyosteatosis is correlated with poor prognosis in some malignancies. The creatinine-to-cystatin ratio (CCR) is revealed to predict gastric cancer prognosis. However, the prognostic abilities of CCR and the combination of CCR and myosteatosis in patients with pancreatic cancer (PC) who underwent radical surgery remains unclear.

methodsThe retrospective cohort study included 215 patients with PC who underwent radical surgery (January 2016-October 2021). Clinicopathological and serological data were collected on admission. Myosteatosis and other body composition indices were assessed by using computed tomography. The cutoff value of CCR was determined by using the Youden index. Risk factors responsible for poor overall survival (OS) and disease-free survival (DFS) were determined by the Cox proportional hazards model.

resultsThe myosteatosis group included 104 patients (average age, 61.3 ± 9.1 years). The best cutoff value for CCR was 1.09. CCR ≤ 1.09 was an independent predictive biomarker inversely corelated with OS (P = 0.036). Myosteatosis was an independent risk factor associated with OS and DFS (P = 0.032 and P = 0.004, respectively). Patients with concomitant myosteatosis and CCR ≤ 1.09 had the worst OS (P = 0.016).

conclusionsMyosteatosis and CCR are prognostic biomarkers for survival in PC patients who underwent radical surgery. Patients with the coexistence of myosteatosis and CCR ≤ 1.09 deserve more attention.

Indexed as

CreatinineCystatin CPancreatic NeoplasmsAgedHumansMiddle AgedPrognosisRetrospective StudiesCreatinineCystatin CCreatinine-to-cystatin C ratioMyosteatosisPancreatic cancerPrognosisRadical surgery

Identifiers

PMID38319516

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.