Evidence map›Paper›PMID 38319473›Full record

ArticleScience China. Life sciences2024

Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A

Yuan Weng, Xinyu Yang, Qiansen Zhang, Ying Chen, Yueming Xu, Chenyu Zhu, Qiong Xie, Yonghui Wang, Huaiyu Yang, Mingyao Liu and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Science China. Life sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Synthesis optimization of AMolecular diversity · 2026
    Article
  2. Pantoprazole as a potential repurposed drug targeting the adenosinergic system in esophageal cancer.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuan Weng *Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Xinyu Yang *Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Qiansen Zhang *Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. qszhang@bio.ecnu.edu.cn.
Ying ChenShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Yueming XuShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Chenyu ZhuDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Qiong XieDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Yonghui WangDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Huaiyu YangShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Mingyao LiuShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Weiqiang LuShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. wqlu@bio.ecnu.edu.cn.
Gaojie SongShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. gjsong@bio.ecnu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The adenosine subfamily G protein-coupled receptors A

Indexed as

Adenosine A2 Receptor AntagonistsMolecular Dynamics SimulationReceptor, Adenosine A2ABinding SitesCrystallography, X-RayHumansLigandsProtein BindingReceptor, Adenosine A2BAdenosine A2 Receptor AntagonistsLigandsReceptor, Adenosine A2AReceptor, Adenosine A2BA2ARA2BRadenosine receptordrug discoverydual-antagonisminhibitor

Identifiers

PMID38319473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.