ArticlemSphere2024
Human saliva modifies growth, biofilm architecture, and competitive behaviors of oral streptococci.
Article in mSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 12 citations in OpenAlex.
- Biofilm-mediated antibiotic tolerance in bacterial pathogens: Integrated molecular networks and novel therapeutic avenues.Virulence · 2026Review
- Article
- Predictors of Dental Caries Increment in Schoolchildren: A Longitudinal Study of Salivary and Behavioral Risk Factors.Dentistry journal · 2026Article
- An Innovative Oral Ex Vivo Biofilm Model for Antimicrobial Investigations.Pathogens (Basel, Switzerland) · 2026Article
- A Defined Artificial Saliva Medium Allows Characterization of the Hypothiocyanite Response of Streptococcus sanguinis and Streptococcus mutans.Molecular oral microbiology · 2025Article
- Genomic and metabonomic insights into the lignin-degrading potential of a novel halophilic bacterial strain Salinicoccus sp. HZC-1.BMC genomics · 2025Article
- Effect of Surface Modification of a Dental Composite on the Adhesion ofPathogens (Basel, Switzerland) · 2025Article
- Seven genome sequences ofMicrobiology resource announcements · 2025Article
- Design, development, and validation of new fluorescent strains for studying oral streptococci.Microbiology spectrum · 2025Article
- Impact of the RaS-RiPP tryglysin and culturing conditions on ex-vivo oral microbiomes.NPJ biofilms and microbiomes · 2025Article
- A strain ofApplied and environmental microbiology · 2025Article
- Article
- A Strain ofbioRxiv : the preprint server for biology · 2024Article
- Guarding the walls: the multifaceted roles of Bce modules in cell envelope stress sensing and antimicrobial resistance.Journal of bacteriology · 2024Review
Corrections and comments
- Erratum issued
- Update of
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The bacteria within supragingival biofilms participate in complex exchanges with other microbes inhabiting the same niche. One example is the mutans group streptococci ( IMPORTANCE: Dental caries (tooth decay) is the most prevalent disease for both children and adults nationwide. Caries are initiated from demineralization of the enamel due to organic acid production through the metabolic activity of oral bacteria growing in biofilm communities attached to the tooth's surface. Mutans group streptococci are closely associated with caries development and initiation of the cariogenic cycle, which decreases the amount of acid-sensitive, health-associated commensal bacteria while selecting for aciduric and acidogenic species that then further drives the disease process. Defining the exchanges that occur between mutans group streptococci and oral commensals in a condition that closely mimics their natural environment is of critical need toward identifying factors that can influence odontopathogen establishment, persistence, and outgrowth. The goal of our research is to develop strategies, potentially through manipulation of microbial interactions characterized here, that prevent the emergence of mutans group streptococci while keeping the protective flora intact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.