Evidence map›Paper›PMID 38318850›Full record

ArticleACS chemical biology2024

Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein.

Jana Volarić, Nieck J van der Heide, Natalie L Mutter, Douwe F Samplonius, Wijnand Helfrich, Giovanni Maglia, Wiktor Szymanski, Ben L Feringa

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Light-Controlled Folding and Chiroptical Sensing of G-Quadruplex DNA.The journal of physical chemistry letters · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Photoswitchable glycoligands targetingBeilstein journal of organic chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jana VolarićStratingh Institute for Organic Chemistry, University of Groningen, 9747 AG Groningen, The Netherlands.
Nieck J van der HeideGroningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG Groningen, The Netherlands.
Natalie L MutterGroningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG Groningen, The Netherlands.ORCID 0000-0002-9144-7443
Douwe F SamploniusDepartment of Surgery, Translational Surgical Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Wijnand HelfrichDepartment of Surgery, Translational Surgical Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Giovanni MagliaGroningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG Groningen, The Netherlands.ORCID 0000-0003-2784-0811
Wiktor SzymanskiStratingh Institute for Organic Chemistry, University of Groningen, 9747 AG Groningen, The Netherlands.
Ben L FeringaStratingh Institute for Organic Chemistry, University of Groningen, 9747 AG Groningen, The Netherlands.ORCID 0000-0003-0588-8435
University of Groningen · NLUniversity Medical Center Groningen · NL

Funding

European Research Council
6 · The paper itself

Abstract

Enabling control over the bioactivity of proteins with light, along with the principles of photopharmacology, has the potential to generate safe and targeted medical treatments. Installing light sensitivity in a protein can be achieved through its covalent modification with a molecular photoswitch. The general challenge in this approach is the need for the use of low energy visible light for the regulation of bioactivity. In this study, we report visible light control over the cytolytic activity of a protein. A water-soluble visible-light-operated tetra-

Indexed as

Azo CompoundsLightHumansIsomerismPorinsProteinsazobenzeneAzo CompoundsPorinsProteins

Identifiers

PMID38318850
PMCPMC10877574
OpenAlexW4391565715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.