Evidence map›Paper›PMID 38318848›Full record

ArticleTissue engineering. Part A2024

Continuous Low-Intensity Ultrasound Improves Cartilage Repair in Rabbit Model of Subchondral Injury.

Anuradha Subramanian, Sarayu Bhogoju, Oraine Snaith, April D Miller, Heather Newell, Denzhi Wang, Gene Siegal, Katelin Oborny, Jesse Baumann-Berg, Hendrik Viljoen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part A, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Anuradha SubramanianDepartment of Chemical and Materials Engineering, The University of Alabama-Huntsville, Huntsville, Alabama, USA.
Sarayu BhogojuDepartment of Chemical and Materials Engineering, The University of Alabama-Huntsville, Huntsville, Alabama, USA.
Oraine SnaithLife Sciences Annex, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
April D MillerDepartment of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Heather NewellDepartment of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Denzhi WangLife Sciences Annex, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Gene SiegalLife Sciences Annex, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Katelin ObornyLife Sciences Annex, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Jesse Baumann-BergLife Sciences Annex, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Hendrik ViljoenDepartment of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
University of Nebraska–Lincoln · US

Funding

Biomimetic Nanofibrillar Scaffolds For Cartilage Tissue EngineeringR21EB006046 · NIBIB · UNIVERSITY OF NEBRASKA LINCOLN · PI SUBRAMANIAN, ANURADHA · 2007 to 2008
$391k
Achieving Integrative Cartilage Repair Success Under Low Intensity UltrasoundR03AG062730 · NIA · UNIVERSITY OF ALABAMA IN HUNTSVILLE · PI SUBRAMANIAN, ANURADHA · 2019 to 2020
$148k
NIA NIH HHS R03 AG062730NIBIB NIH HHS R21 EB006046
6 · The paper itself

Abstract

Subchondral drilling (SD), a bone marrow stimulation technique, is used to repair cartilage lesions that lack regenerative potential. Cartilage repair outcomes upon SD are typically fibrocartilaginous in nature with inferior functionality. The lack of cues to foster the chondrogenic differentiation of egressed mesenchymal stromal cells upon SD can be attributed for the poor outcomes. Continuous low-intensity ultrasound (cLIUS) at 3.8 MHz is proposed as a treatment modality for improving cartilage repair outcomes upon marrow stimulation. Bilateral defects were created by SD on the femoral medial condyle of female New Zealand white rabbits (

Indexed as

Cartilage, ArticularTumor Necrosis Factor-alphaAnimalsCollagenFemaleGene Expression RegulationGlycosaminoglycansRabbitsUltrasonographyCollagenGlycosaminoglycansTumor Necrosis Factor-alphaanimal modelcartilage repairchondroprotectivemicrofractureultrasound

Identifiers

PMID38318848
PMCPMC11040182
OpenAlexW4391576576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.