Evidence map›Paper›PMID 38318686›Full record

ArticleFEBS open bio2024

Oncogenic K-Ras

Mai Ito, Nobuhiro Tanuma, Yui Kotani, Kokoro Murai, Ayumi Kondo, Mami Sumiyoshi, Hiroshi Shima, Satoshi Matsuda, Toshio Watanabe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mai ItoDepartment of Biological Science, Graduate School of Humanities and Sciences, Nara Women's University, Japan.
Nobuhiro TanumaDivision of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Japan.ORCID 0000-0001-7914-1380
Yui KotaniDepartment of Biological Science, Graduate School of Humanities and Sciences, Nara Women's University, Japan.
Kokoro MuraiDepartment of Biological Science, Graduate School of Humanities and Sciences, Nara Women's University, Japan.
Ayumi KondoDepartment of Biological Science, Graduate School of Humanities and Sciences, Nara Women's University, Japan.
Mami SumiyoshiDepartment of Cell Signaling, Institute of Biomedical Science, Kansai Medical University, Hirakata, Japan.
Hiroshi ShimaDivision of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Japan.
Satoshi MatsudaDepartment of Cell Signaling, Institute of Biomedical Science, Kansai Medical University, Hirakata, Japan.
Toshio WatanabeDepartment of Biological Science, Graduate School of Humanities and Sciences, Nara Women's University, Japan.ORCID 0009-0008-2216-1581
Nara Women's University · JPKansai Medical University · JPMiyagi Prefectural Hospital Organization · JP

Funding

Japan Society for the Promotion of Science 20K06545Nara Women's University
6 · The paper itself

Abstract

Protein phosphatase 6 is a Ser/Thr protein phosphatase and its catalytic subunit is Ppp6c. Ppp6c is thought to be indispensable for proper growth of normal cells. On the other hand, loss of Ppp6c accelerates growth of oncogenic Ras-expressing cells. Although it has been studied in multiple contexts, the role(s) of Ppp6c in cell proliferation remains controversial. It is unclear how oncogenic K-Ras overcomes cell proliferation failure induced by Ppp6c deficiency; therefore, in this study, we attempted to shed light on how oncogenic K-Ras modulates tumor cell growth. Contrary to our expectations, loss of Ppp6c decreased proliferation, anchorage-independent growth in soft agar, and tumor formation of oncogenic Ras-expressing mouse embryonic fibroblasts (MEFs). These findings show that oncogenic K-Ras

Indexed as

FibroblastsPhosphoprotein PhosphatasesProto-Oncogene Proteins p21(ras)AnimalsCell ProliferationMiceHras protein, mousePhosphoprotein Phosphatasesprotein phosphatase 6Proto-Oncogene Proteins p21(ras)cell proliferationK‐RasG12VMEFPP6Ppp6ctumor formation

Identifiers

PMID38318686
PMCPMC10988750
OpenAlexW4391612723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.