Evidence map›Paper›PMID 38318660›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

Antigen stasis and airway nitrosative stress in human primary ciliary dyskinesia.

Benjamin Gaston, Laura A Smith, Michael D Davis, Jessica Saunders, Ivana Daniels, Amjad Horani, Steven L Brody, Olivia Giddings, Yi Zhao, Nadzeya Marozkina

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Utilising human cellular models of primary ciliary dyskinesia: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Article
  3. Preclinical human models of primary ciliary dyskinesia.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Ciliary Function, Antigen Stasis and Asthma.International journal of molecular sciences · 2024
    Review
  9. Primary Ciliary Dyskinesia.Pediatrics · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Benjamin GastonHerman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Laura A SmithHerman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States.ORCID 0000-0002-4694-0482
Michael D DavisHerman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Jessica SaundersHerman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Ivana DanielsHerman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Amjad HoraniDepartment of Medicine, Washington University, St. Louis, Missouri, United States.ORCID 0000-0002-5352-1948
Steven L BrodyDepartment of Medicine, Washington University, St. Louis, Missouri, United States.
Olivia GiddingsDepartment of Medicine, Case Western Reserve University, Cleveland, Ohio, United States.
Yi ZhaoDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Nadzeya MarozkinaHerman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States.ORCID 0000-0001-8610-588X
Riley Hospital for Children · USWashington University in St. Louis · USCase Western Reserve University · USIndiana University School of Medicine

Funding

Project 3 - Personalized cystic fibrosis treatment strategies with synergistic therapies Identified in vitro.P01HL128192 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN · 2016 to 2020
$12.2M
S-nitrosylation signaling in asthmaP01HL158507 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN · 2021 to 2025
$12.0M
REGULATION OF MOTILE CILIA ASSEMBLY IN LUNG DISEASER01HL128370 · NHLBI · WASHINGTON UNIVERSITY · PI Steven Brody, SUSAN K DUTCHER · 2015 to 2026
$6.9M
Cellular and Molecular Features of Gene Mutations in Primary Ciliary DyskinesiaR01HL146601 · NHLBI · WASHINGTON UNIVERSITY · PI BRODY, STEVEN · 2019 to 2022
$2.3M
NHLBI NIH HHS P01 HL128192NHLBI NIH HHS P01 HL158507NHLBI NIH HHS R01 HL128370NHLBI NIH HHS R01 HL146601
6 · The paper itself

Abstract

Nasal nitric oxide (nNO) is low in most patients with primary ciliary dyskinesia (PCD). Decreased ciliary motion could lead to antigen stasis, increasing oxidant production and NO oxidation in the airways. This could both decrease gas phase NO and increase nitrosative stress. We studied primary airway epithelial cells from healthy controls (HCs) and patients with PCD with several different genotypes. We measured antigen clearance in fenestrated membranes exposed apically to the fluorescently labeled antigen

Indexed as

Ciliary Motility DisordersKartagener SyndromeBiomarkersBreath TestsHumansHydrogen PeroxideNitric OxideNitrosative StressBiomarkersHydrogen PeroxideNitric OxideDUOX1nasal NOnitrosative stressoxidationprimary ciliary dyskinesia

Identifiers

PMID38318660
PMCPMC11281798
OpenAlexW4391574992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.