Evidence map›Paper›PMID 38318491›Full record

ArticleSynthetic and systems biotechnology2024

Coupled strategy based on regulator manipulation and medium optimization empowers the biosynthetic overproduction of lincomycin.

Xinlu Cai, Wanlian Xu, Yang Zheng, Sendi Wu, Rundong Zhao, Nian Wang, Yaqian Tang, Meilan Ke, Qianjin Kang, Linquan Bai and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic and systems biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Improving butenyl-spinosyn production inFrontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xinlu CaiSchool of Life Sciences, Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
Wanlian XuSchool of Life Sciences, Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
Yang ZhengSchool of Life Sciences, Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
Sendi WuSchool of Life Sciences, Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
Rundong ZhaoSchool of Life Sciences, Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
Nian WangSchool of Life Sciences, Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
Yaqian TangSchool of Life Sciences, Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
Meilan KeSchool of Life Sciences, Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
Qianjin KangState Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, 200240, China.
Linquan BaiState Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, 200240, China.
Buchang ZhangSchool of Life Sciences, Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
Hang WuSchool of Life Sciences, Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biosynthesis of bioactive secondary metabolites, specifically antibiotics, is of great scientific and economic importance. The control of antibiotic production typically involves different processes and molecular mechanism. Despite numerous efforts to improve antibiotic yields, joint engineering strategies for combining genetic manipulation with fermentation optimization remain finite. Lincomycin A (Lin-A), a lincosamide antibiotic, is industrially fermented by

Indexed as

Fermentation optimizationGenetic engineeringLincomycinStreptomycesTranscription factor

Identifiers

PMID38318491
PMCPMC10840354

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.