Evidence map›Paper›PMID 38318477›Full record

ArticleMaterials today. Bio2024

Multi-targeting inulin-based nanoparticles with cannabidiol for effective prevention of ulcerative colitis.

Xuan Zhang, Xia Gao, Xiangzhou Yi, Hui Yu, Mingyang Shao, Yongcheng Li, Xuanri Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  15. Foods (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xuan ZhangCollege of Food Science and Engineering, Hainan University, Haikou, 570228, China.
Xia GaoCollege of Food Science and Engineering, Hainan University, Haikou, 570228, China.
Xiangzhou YiCollege of Food Science and Engineering, Hainan University, Haikou, 570228, China.
Hui YuCollege of Food Science and Engineering, Hainan University, Haikou, 570228, China.
Mingyang ShaoCollege of Food Science and Engineering, Hainan University, Haikou, 570228, China.
Yongcheng LiCollege of Food Science and Engineering, Hainan University, Haikou, 570228, China.
Xuanri ShenCollege of Food Science and Engineering, Hainan University, Haikou, 570228, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenesis of ulcerative colitis (UC) is closely related to severe inflammation, damaged colonic mucosal barrier, increased oxidative stress and intestinal ecological imbalance. However, due to the nonspecific distribution and poor bioavailability of drugs, UC treatment is still a serious challenge. Here, a mitochondria/colon dual targeted nanoparticles based on redox response was developed to effectively alleviate UC. Cannabidiol nanoparticles (CBD NPs) with a particle size of 143.2 ± 3.11 nm were prepared by self-assembly using polymers (TPP-IN-LA) obtained by modifying inulin with (5-carboxypentyl) triphenyl phosphonium bromide (TPP) and α-lipoic acid (α-LA). Excitingly, the constructed CBD NPs showed excellent mitochondrial targeting, with a Pearson correlation coefficient of 0.76 at 12 h. The results of animal imaging

Indexed as

CannabidiolInulinMulti-targetingNanoparticlesUlcerative colitis

Identifiers

PMID38318477
PMCPMC10839446

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.