Evidence map›Paper›PMID 38318387›Full record

ArticleiScience2024

Plasma and urine proteomics and gut microbiota analysis reveal potential factors affecting COVID-19 vaccination response.

Changjiang Hu, Weichao Hu, Bo Tang, Qiyu Bao, Xingyu Jiang, Li Tang, He Wang, Lijiao He, Moyang Lv, Yufeng Xiao and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Changjiang HuDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Weichao HuDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Bo TangDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Qiyu BaoDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Xingyu JiangLaboratory Medicine Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Li TangDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
He WangiMarkerlab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province, China.
Lijiao HeDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Moyang LvDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Yufeng XiaoDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Cheng LiuDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Xinzhe LiDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Yunyi LiuDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Jie LiDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Guiping HuangDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Zhen DongiMarkerlab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province, China.
Zhongjun LiLaboratory Medicine Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Tiannan GuoiMarkerlab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province, China.
Shiming YangDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficacy of COVID-19 vaccination relies on the induction of neutralizing antibodies, which can vary among vaccine recipients. In this study, we investigated the potential factors affecting the neutralizing antibody response by combining plasma and urine proteomics and gut microbiota analysis. We found that activation of the LXR/FXR pathway in plasma was associated with the production of ACE2-RBD-inhibiting antibodies, while urine proteins related to complement system, acute phase response signaling, LXR/FXR, and STAT3 pathways were correlated with neutralizing antibody production. Moreover, we observed a correlation between the gut microbiota and plasma and urine proteins, as well as the vaccination response. Based on the above data, we built a predictive model for vaccination response (AUC = 0.85). Our study provides insights into characteristic plasma and urine proteins and gut microbiota associated with the ACE2-RBD-inhibiting antibodies, which could benefit our understanding of the host response to COVID-19 vaccination.

Indexed as

Experimental models in systems biologyHealth sciencesImmunityMicrobiologyProteomics

Identifiers

PMID38318387
PMCPMC10838952

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.