Evidence map›Paper›PMID 38318375›Full record

ArticleiScience2024

Genetic and chemical disruption of amyloid precursor protein processing impairs zebrafish sleep maintenance.

Güliz Gürel Özcan, Sumi Lim, Thomas Canning, Lavitasha Tirathdas, Joshua Donnelly, Tanushree Kundu, Jason Rihel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Güliz Gürel ÖzcanDepartment of Cell and Developmental Biology, University College London, London, UK.
Sumi LimDepartment of Cell and Developmental Biology, University College London, London, UK.
Thomas CanningDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Lavitasha TirathdasDepartment of Cell and Developmental Biology, University College London, London, UK.
Joshua DonnellyDepartment of Cell and Developmental Biology, University College London, London, UK.
Tanushree KunduDepartment of Cell and Developmental Biology, University College London, London, UK.
Jason RihelDepartment of Cell and Developmental Biology, University College London, London, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Amyloid precursor protein (APP) is a brain-rich, single pass transmembrane protein that is proteolytically processed into multiple products, including amyloid-beta (Aβ), a major driver of Alzheimer disease (AD). Although both overexpression of APP and exogenously delivered Aβ lead to changes in sleep, whether APP processing plays an endogenous role in regulating sleep is unknown. Here, we demonstrate that APP processing into Aβ40 and Aβ42 is conserved in zebrafish and then describe sleep/wake phenotypes in loss-of-function

Indexed as

Biological sciencesMolecular geneticsMolecular neuroscience

Identifiers

PMID38318375
PMCPMC10839650

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.