Evidence map›Paper›PMID 38317903›Full record

ArticleHeliyon2024

The causal effect of oxidative stress on the risk of glaucoma.

Ronghua Shi, Yaxuan Wu, He Chen, Zicheng Zhang, Siqi Bao, Jia Qu, Meng Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ronghua ShiSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou 570228, China.
Yaxuan WuSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou 570228, China.
He ChenSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou 570228, China.
Zicheng ZhangSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou 570228, China.
Siqi BaoSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou 570228, China.
Jia QuSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou 570228, China.
Meng ZhouNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glaucoma is a complex multifactorial disease. Oxidative stress has been implicated in its pathogenesis. However, establishing a causal relationship between oxidative stress and glaucoma is challenging due to confounding and reverse causality. In this study, we performed bidirectional two-sample Mendelian randomization (MR) analyses based on genetic instrumental variables as proxies for 11 biomarkers of oxidative stress injury to investigate the causal relationship between oxidative stress and glaucoma. Eight significant associations were identified. Increased circulating levels of catalase (OR = 0.915, 95 % CI: 0.848-0.987,

Indexed as

GlaucomaMendelian randomization studyOxidative stress

Identifiers

PMID38317903
PMCPMC10838757

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.