ArticleKidney medicine2024
Kidney Function and Physical Performance Decline: The Brain in Kidney Disease (BRINK) Cohort Study.
Article in Kidney medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The trial behind it
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Who cites it
7 citing papers in PubMed.
- Predictors of physical performance decline in patients receiving maintenance hemodialysis: a prospective observational study.BMC nephrology · 2026Observational
- Renal function and comprehensive frailty in community-dwelling older adults: cross-sectional and longitudinal analyses.Clinical and experimental nephrology · 2026Article
- Associations of exercise habits with physical function and emergency dialysis start in patients with end-stage renal disease before dialysis initiation.Clinical and experimental nephrology · 2026Article
- Physical Function Decline Among Adults With Moderate-to-Severe CKD.Kidney international reports · 2026Article
- Drug Burden Index and Its Association With Functional Outcomes in Patients Receiving Hemodialysis.Kidney medicine · 2026Article
- Physical Function and Mortality in Older Adults with Chronic Kidney Disease.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
- Ripple Effects: CKD and Physical Function.Kidney medicine · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Rationale & Objective: Patients with kidney failure have poor physical performance, but its trajectory is less clear. We examined physical function over the course of kidney disease, including the transition to dialysis. Study Design: Observational cohort. Setting & Participants: Community-dwelling adults aged ≥45 years in the Brain in Kidney Disease (BRINK) cohort study. Predictors: Estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (UACR). Outcomes: Change in physical performance using the Short Physical Performance Battery (SPPB) (primary) and gait speed (secondary). Analytical Approach: Linear mixed effects regression models. Results: The analytical cohort included 562 participants with mean age of 69.3 (SD, 9.8) years followed for up to 63 months. In total, 49.8% were women. In addition, 79.9% self-identified as White, and 15.3% self-identified as Black. In total, 48.8% had diabetes. Mean eGFR at baseline was 48.1 (SD, 24.3) mL/min/1.73 m Limitations: Small number of participants started dialysis. Conclusions: We found a graded association of chronic kidney disease stage and albuminuria with decline in physical performance. The decline in SPPB was not accelerated after dialysis initiation in covariate-adjusted models, whereas gait speed continued to decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.