Evidence map›Paper›PMID 38317745›Full record

ArticleTranslational gastroenterology and hepatology2024

Successful adult domino living donor liver transplantation in methylmalonic acidemia: case report.

Alicia J Chorley, Turkan Terkivatan, Jeroen de Jonge, Wojtek G Polak, Khe T C Tran, Carsten Unkhoff, Caroline M den Hoed, Margreet A E M Wagenmakers, Jan N M Ijzermans, Robert C Minnee and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Translational gastroenterology and hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alicia J ChorleyErasmus MC Transplant Institute, Division of HPB & Transplant Surgery, Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Turkan TerkivatanErasmus MC Transplant Institute, Division of HPB & Transplant Surgery, Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jeroen de JongeErasmus MC Transplant Institute, Division of HPB & Transplant Surgery, Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Wojtek G PolakErasmus MC Transplant Institute, Division of HPB & Transplant Surgery, Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Khe T C TranErasmus MC Transplant Institute, Division of HPB & Transplant Surgery, Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Carsten UnkhoffDepartment of Anesthesiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Caroline M den HoedErasmus MC Transplant Institute, Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Margreet A E M WagenmakersDepartment of Internal Medicine, Center for Lysosomal and Metabolic Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jan N M IjzermansErasmus MC Transplant Institute, Division of HPB & Transplant Surgery, Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Robert C MinneeErasmus MC Transplant Institute, Division of HPB & Transplant Surgery, Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Markus U BoehnertErasmus MC Transplant Institute, Division of HPB & Transplant Surgery, Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Liver transplantation (LT) is a therapeutic option in multiple inherited metabolic diseases (IMDs), including methylmalonic acidemia (MMA), as LT reduces the risk of acute metabolic decompensations and long-term complications associated with these diseases. In certain IMDs, such as maple syrup urine disease (MSUD), domino liver transplant (DLT) is an accepted and safe method which expands the donor pool. However, only one adult case of DLT using an MMA donor liver has been reported; outcome and safety are still unknown and questioned. Case Description: In this case report, we describe our experience with DLT using MMA livers. Two adult MMA patients underwent living donor liver transplant (LDLT); their MMA livers were consecutively transplanted into two patients on the liver transplant waiting list who had limited chance of receiving a liver transplant in the short term due to their low model for end-stage liver disease (MELD) scores. No severe peri- or postoperative complications occurred, however the recipients of the MMA livers biochemically now have mild MMA. Conclusions: DLT using MMA grafts is a feasible strategy to treat end-stage liver disease and expand the donor organ pool. However, the recipient of the MMA domino liver may develop mild MMA which could affect quality of life, and long-term safety remains unclear. Further long-term of outcomes for domino recipients of MMA livers, focusing on quality of life and any metabolic complications of transplantation are needed to better define the risks and benefits.

Indexed as

case reportdomino liver transplant (DLT)living donor liver transplant (LDLT)Methylmalonic acidemia (MMA)

Identifiers

PMID38317745
PMCPMC10838613

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