Evidence map›Paper›PMID 38317706›Full record

ArticleArthroplasty today2024

The Location of Biofilms on Chronic Prosthetic Joint Infections and the Ramifications for Clinical Practice.

James B Doub, David Parmiter, Christine A Brantner, Matthew Moshyedi, Meghan Hughes, Matthew Kolevar, Aaron Johnson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthroplasty today, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Biofilm-associated genes inFrontiers in microbiology · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James B DoubThe Doub Laboratory of Translational Bacterial Research, University of Maryland School of Medicine, Baltimore, MD, USA.
David ParmiterElectron Microscopy Core Imaging Facility, University of Maryland Baltimore, Baltimore, MD.
Christine A BrantnerElectron Microscopy Core Imaging Facility, University of Maryland Baltimore, Baltimore, MD.
Matthew MoshyediUniversity of Maryland School of Medicine, Baltimore, MD.
Meghan HughesDepartment of Orthopedic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Matthew KolevarDepartment of Orthopedic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Aaron JohnsonDepartment of Orthopedic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Revision surgery is paramount to cure chronic prosthetic joint infections because these infections are associated with biofilms on prosthetics that conventional antibiotics cannot eradicate. However, there is a paucity of research on where in vivo biofilms are located on infected prosthetics. Consequently, the objective of this pilot study was to address this gap in knowledge by staining 5 chronically infected prosthetics, that were removed at the time of revision surgery, with methylene blue. Scanning electron microscopic images were then taken of the methylene blue-stained areas to visualize biofilms. The findings show that all chronically infected prosthetics had biofilms located on the bone-prosthetic interface, yet only 2 had biofilms also located on the prosthetic interface exposed to synovial fluid. Subsequently, this pilot study provides a pathophysiological understanding of why the current treatment paradigm for chronic periprosthetic joint infection requires a revision surgery and not debridement and an implant retention surgery.

Indexed as

BiofilmMethylene bluePeriprosthetic joint infectionsScanning electron microscopySEM

Identifiers

PMID38317706
PMCPMC10839572

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.