ReviewTransplant international : official journal of the European Society for Organ Transplantation2024
The Advent of Semi-Elective Lung Transplantation-Prolonged Static Cold Storage at 10°C.
Review in Transplant international : official journal of the European Society for Organ Transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- 10 °C Storage for the Preservation of Pig Kidney Grafts: A Porcine Autotransplant Model.Transplantation direct · 2026Article
- Optimizing Lung Transplant Logistics Using Controlled Hypothermic Preservation to Extend Ischemic Time.Transplantation direct · 2026Article
- Safety in the transport of substances of human origin: a critical challenge for the quality of transplants.Sao Paulo medical journal = Revista paulista de medicina · 2026Article
- Key role of the endothelium in lung ischemia-reperfusion injury: What the clinician needs to know.JHLT open · 2026Review
- ERS Congress 2025: highlights from the Thoracic Surgery and Lung Transplantation Assembly.ERJ open research · 2026Article
- Cardiothoracic Transplant Surgery and Enhanced Recovery: Recent Advances and Perspectives.Journal of clinical medicine · 2026Review
- One-year clinical outcomes of an observational study of static lung preservation at 10° centigrade and semi-elective lung transplantation.JHLT open · 2025Article
- Incidental Cold Agglutinins in Lung Transplant Recipients.Transplantation direct · 2025Article
- Ten hour donor heart ischemic time with 10ºC static storage.JHLT open · 2025Article
- Innovations in Lung Transplant Research and Practice: The Future is Now.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Organ preservation: current limitations and optimization approaches.Frontiers in medicine · 2025Review
- European Society of Organ Transplantation (ESOT) Consensus Statement on Machine Perfusion in Cardiothoracic Transplant.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the early days of clinical lung transplantation the preservation of donor organs has become a fairly standardized procedure and most centers do follow similar processes. This includes the use of low-potassium high dextran flush solutions and static cold storage (SCS) in a cooler filled with ice. Depending on the length of SCS, organs usually arrive at the recipient hospital at a temperature of 0°C-4°C. The question of the optimal storage temperature for donor lung preservation has been revisited as data from large animal experiments demonstrated that organs stored at 10°C experience less mitochondrial damage. Thus, prolonged cold ischemic times can be better tolerated at 10°C-even in pre-damaged organs. The clinical applicability of these findings was demonstrated in an international multi-center observational study including three high-volume lung transplant centers. Total clinical preservation times of up to 24 hrs have been successfully achieved in organs stored at 10°C without hampering primary organ function and short-term outcomes. Currently, a randomized-controlled trial (RCT) is recruiting patients with the aim to compare standard SCS on ice with prolonged SCS protocol at 10°C. If, as anticipated, this RCT confirms data from previous studies, lung transplantation could indeed become a semi-elective procedure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.