Evidence map›Paper›PMID 38317471›Full record

ArticlePharmaceutical nanotechnology2025

Characterizing Nanoparticle Isolated by Yam Bean (

Maesa Ranggawati Kusnandar, Indra Wibowo, Anggraini Barlian

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Article in Pharmaceutical nanotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  10. Plant-derived extracellular vesicles in facial aesthetics.Extracellular vesicles and circulating nucleic acids · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maesa Ranggawati KusnandarSchool of Life Science and Technology, Institut Teknologi Bandung, Bandung, West Java, Indonesia.
Indra WibowoSchool of Life Science and Technology, Institut Teknologi Bandung, Bandung, West Java, Indonesia.
Anggraini BarlianSchool of Life Science and Technology, Institut Teknologi Bandung, Bandung, West Java, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study investigated the potential of Plant-Derived Exosome-Like Nanoparticles (PDENs) as cosmeceutical nanocarriers for treating skin problems, such as scar removal, face rejuvenation, anti-aging, and anti-pigmentation.

objectivesResearchers isolated PDENs from Yam Bean ((

methodsThe morphology of the YB-PDENs was determined using TEM analysis, they had a spherical shape with diameters of 236,83 ± 9,27 nm according to PSA. The study found that YB-PDENs were stable in aquabidest at 4°C for one month of storage and had ~-26,5 mV of Zeta Potential. The concentration of YB-PDENs was measured using the BCA Assay, and internalization of YB-PDENs to HDF cells was observed using a Confocal Laser Scanning Microscope labelled with PKH67.

resultsAs for cytotoxicity, after 24 and 72 hours of incubation with YB-PDENs, the viability of HDF cells remained more than 80%. The study also examined cell migration using the Scratch Assay and found that at 2,5 μg/mL, YB-PDENs had better migration results than other concentrations. Immunocytochemistry showed that collagen expression was higher after 14 days of incubation with YBPDENs, and melanocytes in zebrafish decreased at each concentration compared with controls.

conclusionIn conclusion, this study is the first to extract and describe PDEN s from Yam Bean ((

Indexed as

NanoparticlesPlant ExtractsAnimalsCell LineCell MovementCell SurvivalHumansParticle SizeZebrafishPlant Extractsanalysis.anti-melanogenic activityExosomePachyrhizus erosusplant-derived exosome-like nanoparticleYB-PDENs

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.