Evidence map›Paper›PMID 38317378›Full record

ArticleACS synthetic biology2024

Degron-Controlled Protein Degradation in

Glen E Cronan, Andrei Kuzminov

Abstract read
PubMed Publisher
In one paragraph

Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Cell Sizes Matter for Industrial Bioproduction, a Case of Polyhydroxybutyrate.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Glen E CronanDepartment of Microbiology, University of Illinois at Urbana─Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0001-7092-6595
Andrei KuzminovDepartment of Microbiology, University of Illinois at Urbana─Champaign, Urbana, Illinois 61801, United States.
University of Illinois Urbana-Champaign · US

Funding

Chromosomal death due to misincorporation of wrong material into DNAR01GM073115 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KUZMINOV, ANDREI · 2007 to 2022
$3.6M
Synergistic toxicity of reactive oxygen speciesR01GM132484 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KUZMINOV, ANDREI · 2020 to 2023
$1.2M
NIGMS NIH HHS R01 GM073115NIGMS NIH HHS R01 GM132484
6 · The paper itself

Abstract

Protein degron tags have proven to be uniquely useful for the characterization of gene function. Degrons can mediate quick depletion, usually within minutes, of a protein of interest, allowing researchers to characterize cellular responses to the loss of function. To develop a general-purpose degron tool in

Indexed as

Escherichia coliEscherichia coli ProteinsAdenosine TriphosphatasesCarrier ProteinsDegronsEndopeptidase ClpProteolysisAdenosine TriphosphatasesCarrier ProteinsEndopeptidase ClpEscherichia coli ProteinsClpXP proteasedegronRecARuvBSspB adaptor

Identifiers

PMID38317378
OpenAlexW4391568381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.