Evidence map›Paper›PMID 38317104›Full record

ArticleBMC cancer2024

The effects of short-term, progressive exercise training on disease activity in smouldering multiple myeloma and monoclonal gammopathy of undetermined significance: a single-arm pilot study.

A Emery, S Moore, J Crowe, J Murray, O Peacock, D Thompson, F Betts, S Rapps, L Ross, D Rothschild-Rodriguez and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Feasibility and safety of impact-loading exercise in patients with multiple myeloma-a pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

A EmeryDepartment for Health, University of Bath, Bath, UK.
S MooreDepartment for Haematology, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.
J CroweDepartment for Haematology, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.
J MurrayDepartment for Haematology, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.
O PeacockDepartment for Health, University of Bath, Bath, UK.
D ThompsonDepartment for Health, University of Bath, Bath, UK.
F BettsDepartment for Health, University of Bath, Bath, UK.
S RappsDepartment for Health, University of Bath, Bath, UK.
L RossDepartment for Health, University of Bath, Bath, UK.
D Rothschild-RodriguezSchool of Biological Sciences, University of Southampton, Southampton, UK.
A Arana EcharriDepartment for Health, University of Bath, Bath, UK.
R DaviesDepartment for Health, University of Bath, Bath, UK.
R LewisDepartment for Physiotherapy, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.
D X AugustineDepartment for Health, University of Bath, Bath, UK.
A WhitewayDepartment for Haematology, North Bristol NHS Trust, Bristol, UK.
Z AfzalClinical Immunology Service, Institute of Immunity and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Jlj HeaneyClinical Immunology Service, Institute of Immunity and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
M T DraysonClinical Immunology Service, Institute of Immunity and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
J E TurnerDepartment for Health, University of Bath, Bath, UK.
J P CampbellDepartment for Health, University of Bath, Bath, UK. J.Campbell@bath.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh levels of physical activity are associated with reduced risk of the blood cancer multiple myeloma (MM). MM is preceded by the asymptomatic stages of monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM) which are clinically managed by watchful waiting. A case study (N = 1) of a former elite athlete aged 44 years previously indicated that a multi-modal exercise programme reversed SMM disease activity. To build from this prior case study, the present pilot study firstly examined if short-term exercise training was feasible and safe for a group of MGUS and SMM patients, and secondly investigated the effects on MGUS/SMM disease activity.

methodsIn this single-arm pilot study, N = 20 participants diagnosed with MGUS or SMM were allocated to receive a 16-week progressive exercise programme. Primary outcome measures were feasibility and safety. Secondary outcomes were pre- to post-exercise training changes to blood biomarkers of MGUS and SMM disease activity- monoclonal (M)-protein and free light chains (FLC)- plus cardiorespiratory and functional fitness, body composition, quality of life, blood immunophenotype, and blood biomarkers of inflammation.

resultsFifteen (3 MGUS and 12 SMM) participants completed the exercise programme. Adherence was 91 ± 11%. Compliance was 75 ± 25% overall, with a notable decline in compliance at intensities > 70% V̇O

conclusionsA 16-week progressive exercise programme was feasible and safe, but did not reverse MGUS/SMM disease activity, contrasting a prior case study showing that five years of exercise training reversed SMM in a 44-year-old former athlete. Longer exercise interventions should be explored in a group of MGUS/SMM patients, with measurements of disease biomarkers, along with rates of disease progression (i.e., MGUS/SMM to MM). REGISTRATION: https://www.isrctn.com/ISRCTN65527208 (14/05/2018).

Indexed as

Monoclonal Gammopathy of Undetermined SignificanceMultiple MyelomaParaproteinemiasSmoldering Multiple MyelomaAdultBiomarkersDisease ProgressionExerciseHumansPilot ProjectsQuality of LifeBiomarkersAerobic exerciseAnti-cancer mechanismsCancer precursorsCancer riskExercise oncologyResistance exercise

Identifiers

PMID38317104
PMCPMC10840198

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.