Evidence map›Paper›PMID 38317012›Full record

ArticleMolecular psychiatry2024

Effects of transcranial magnetic stimulation on the human brain recorded with intracranial electrocorticography.

Jeffrey B Wang, Umair Hassan, Joel E Bruss, Hiroyuki Oya, Brandt D Uitermarkt, Nicholas T Trapp, Phillip E Gander, Matthew A Howard, Corey J Keller, Aaron D Boes

Registry-linked trialAbstract read
In one paragraph

Article in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07518745 (Mapping Transcrnial Magnetic Stimulation), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07518745 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Mapping Transcrnial Magnetic Stimulation (TMS) Responses Within the Brain Using Intracranial Electrophysiological Monitoring Recordings

TypeinterventionalSponsorUniversity of PennsylvaniaRan2025 to 2029Enrolled10ConditionsEEG, TMSArmsSingle Pulse TMS
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Efficacy of neuromodulation and rehabilitation approaches on pain relief in patients with spinal cord injury: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  16. Sensory Entrained TMS (seTMS) enhances motor cortex plasticity.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jeffrey B Wang *Biophysics Graduate Program, Stanford University Medical Center, Stanford, CA, 94305, USA.ORCID 0000-0002-8933-9822
Umair Hassan *Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA, 94305, USA.
Joel E BrussDepartment of Neurology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Hiroyuki OyaDepartment of Neurosurgery, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.ORCID 0000-0002-1733-5478
Brandt D UitermarktDepartment of Pediatrics, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Nicholas T TrappDepartment of Psychiatry, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Phillip E GanderDepartment of Neurosurgery, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.ORCID 0000-0003-3945-8820
Matthew A HowardDepartment of Neurosurgery, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Corey J KellerDepartment of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA, 94305, USA.ORCID 0000-0003-0529-3490
Aaron D BoesDepartment of Neurology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA. aaron-boes@uiowa.edu.ORCID 0000-0002-7865-9257
University of Iowa · USNeurosciences Institute · USStanford Medicine · US

Funding

HUMAN AUDITORY CORTEX PHYSIOLOGYR01DC004290 · NIDCD · UNIVERSITY OF IOWA · PI HOWARD, MATTHEW A. · 2000 to 2025
$13.7M
The Iowa Neuroscience Specialty Program in Research Education (INSPIRE)T32MH019113 · NIMH · UNIVERSITY OF IOWA · PI HANNA E STEVENS, John A Wemmie · 1991 to 2026
$5.6M
Investigating the neural mechanisms of repetitive brain stimulation with invasive and noninvasive electrophysiology in humansR01MH132074 · NIMH · STANFORD UNIVERSITY · PI Aaron D Boes, Corey J Keller · 2023 to 2026
$3.1M
Predicting Cognitive Outcomes from Stroke Based on Lesion LocationR01NS114405 · NINDS · UNIVERSITY OF IOWA · PI BOES, AARON D · 2020 to 2024
$2.1M
University of Iowa - Research 3T MRI Connectome UpgradeS10OD025025 · OD · UNIVERSITY OF IOWA · PI MAGNOTTA, VINCENT A · 2018 to 2018
$1.9M
Closing the loop: development of real-time, personalized brain stimulationR01MH126639 · NIMH · STANFORD UNIVERSITY · PI KELLER, COREY J · 2021 to 2024
$1.6M
Optimized methods for measuring brain excitability in depressionR01MH139650 · NIMH · STANFORD UNIVERSITY · PI Aaron D Boes, Corey J Keller · 2025 to 2026
$1.5M
CRCNS US-France Research Proposal: Probing the Dorsolateral Prefrontal Cortex and Central Executive Network for Improving Neuromodulation in DepressionR01MH129018 · NIMH · STANFORD UNIVERSITY · PI KELLER, COREY J · 2021 to 2025
$1.1M
Investigating Network Plasticity Effects of Repetitive Brain Stimulation Following Invasive and Noninvasive Methods in HumansK23MH125145 · NIMH · UNIVERSITY OF IOWA · PI TRAPP, NICHOLAS THOMAS · 2021 to 2025
$934k
Investigating the Effects of Transcranial Magnetic Stimulation with Intracranial EEG in HumansR21MH120441 · NIMH · UNIVERSITY OF IOWA · PI BOES, AARON D, OYA, HIROYUKI · 2019 to 2020
$425k
Whole-Brain Oscillatory and Behavioral Responses to Noninvasive Local Ketamine Uncaging in the Medial Prefrontal CortexF30MH119763 · NIMH · STANFORD UNIVERSITY · PI WANG, JEFFREY BOND · 2020 to 2021
$75k
NIDCD NIH HHS R01 DC004290NIH HHS S10 OD025025NIMH NIH HHS F30 MH119763NIMH NIH HHS K23 MH125145NIMH NIH HHS R01 MH126639NIMH NIH HHS R01 MH129018NIMH NIH HHS R01 MH132074NIMH NIH HHS R01 MH139650NIMH NIH HHS R21 MH120441NIMH NIH HHS T32 MH019113NINDS NIH HHS R01 NS114405U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 1R01 MH132074U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 5T32-MH019113U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) F30MH119763U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH129018U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21MH120441U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 4 R01NS114405
6 · The paper itself

Abstract

Transcranial magnetic stimulation (TMS) is increasingly used as a noninvasive technique for neuromodulation in research and clinical applications, yet its mechanisms are not well understood. Here, we present the neurophysiological effects of TMS using intracranial electrocorticography (iEEG) in neurosurgical patients. We first evaluated safety in a gel-based phantom. We then performed TMS-iEEG in 22 neurosurgical participants with no adverse events. We next evaluated intracranial responses to single pulses of TMS to the dorsolateral prefrontal cortex (dlPFC) (N = 10, 1414 electrodes). We demonstrate that TMS is capable of inducing evoked potentials both locally within the dlPFC and in downstream regions functionally connected to the dlPFC, including the anterior cingulate and insular cortex. These downstream effects were not observed when stimulating other distant brain regions. Intracranial dlPFC electrical stimulation had similar timing and downstream effects as TMS. These findings support the safety and promise of TMS-iEEG in humans to examine local and network-level effects of TMS with higher spatiotemporal resolution than currently available methods.

Indexed as

ElectrocorticographyTranscranial Magnetic StimulationAdultBrainBrain MappingDorsolateral Prefrontal CortexElectric StimulationEvoked PotentialsFemaleHumansMaleMiddle AgedYoung Adult

Identifiers

PMID38317012
PMCPMC12574714
OpenAlexW4391533230

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.