Evidence map›Paper›PMID 38316931›Full record

ReviewNature microbiology2024

Mechanistic insights into bone remodelling dysregulation by human viral pathogens.

Camila C S Caetano, Tamiris Azamor, Nikki M Meyer, Chineme Onwubueke, Cassandra M Calabrese, Leonard H Calabrese, Anabelle Visperas, Nicolas S Piuzzi, M Elaine Husni, Suan-Sin Foo and 1 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Camila C S CaetanoInfection Biology Program, Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Tamiris AzamorInfection Biology Program, Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Nikki M MeyerInfection Biology Program, Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Chineme OnwubuekeInfection Biology Program, Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Cassandra M CalabreseDepartment of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA.
Leonard H CalabreseDepartment of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA.
Anabelle VisperasDepartment of Orthopedic Surgery, Cleveland Clinic, Cleveland, OH, USA.
Nicolas S PiuzziDepartment of Orthopedic Surgery, Cleveland Clinic, Cleveland, OH, USA.
M Elaine HusniDepartment of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA.
Suan-Sin Foo *Infection Biology Program, Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. foos@ccf.org.ORCID http://orcid.org/0009-0007-8174-0893
Weiqiang Chen *Infection Biology Program, Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. chenw3@ccf.org.ORCID http://orcid.org/0000-0002-8840-1823
Cleveland Clinic Lerner College of Medicine · USCleveland Clinic · US

Funding

Molecular mechanism of Zika virus-induced premature craniofacial suture closureR01DE033391 · NIDCR · CLEVELAND CLINIC LERNER COM-CWRU · PI Weiqiang Chen · 2024 to 2026
$872k
Molecular regulatory mechanism of Zika virus-induced intracranial calcificationsR00DE028573 · NIDCR · CLEVELAND CLINIC LERNER COM-CWRU · PI CHEN, WEIQIANG · 2022 to 2024
$747k
NIDCR NIH HHS R00 DE028573NIDCR NIH HHS R01 DE033391
6 · The paper itself

Abstract

Bone-related diseases (osteopathologies) associated with human virus infections have increased around the globe. Recent findings have highlighted the intricate interplay between viral infection, the host immune system and the bone remodelling process. Viral infections can disrupt bone homeostasis, contributing to conditions such as arthritis and soft tissue calcifications. Osteopathologies can occur after arbovirus infections such as chikungunya virus, dengue virus and Zika virus, as well as respiratory viruses, such as severe acute respiratory syndrome coronavirus 2 and enteroviruses such as Coxsackievirus B. Here we explore how human viruses dysregulate bone homeostasis, detailing viral factors, molecular mechanisms, host immune response changes and bone remodelling that ultimately result in osteopathologies. We highlight model systems and technologies to advance mechanistic understanding of viral-mediated bone alterations. Finally, we propose potential prophylactic and therapeutic strategies, introduce 'osteovirology' as a research field highlighting the underestimated roles of viruses in bone-related diseases, and discuss research avenues for further investigation.

Indexed as

Arbovirus InfectionsChikungunya virusDengue VirusZika VirusZika Virus InfectionHumans

Identifiers

PMID38316931
PMCPMC11045166
OpenAlexW4391543638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.