Evidence map›Paper›PMID 38316879›Full record

ArticleNature structural & molecular biology2024

Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair.

Goran Kokic, George Yakoub, Diana van den Heuvel, Annelotte P Wondergem, Paula J van der Meer, Yana van der Weegen, Aleksandar Chernev, Isaac Fianu, Thornton J Fokkens, Sonja Lorenz and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Nature structural & molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 51 citations in OpenAlex.

  1. Topology Resetting During Transcription-Coupled Nucleotide Excision Repair.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Goran KokicDepartment of Molecular Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
George YakoubDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-2727-7651
Diana van den HeuvelDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Annelotte P WondergemDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Paula J van der MeerDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-7616-6689
Yana van der WeegenDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Aleksandar ChernevBioanalytical Mass Spectrometry, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Isaac FianuDepartment of Molecular Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID http://orcid.org/0000-0002-8508-114X
Thornton J FokkensUbiquitin Signaling Specificity, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Sonja LorenzUbiquitin Signaling Specificity, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID http://orcid.org/0000-0002-9639-2381
Henning UrlaubBioanalytical Mass Spectrometry, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID http://orcid.org/0000-0003-1837-5233
Patrick CramerDepartment of Molecular Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. patrick.cramer@mpinat.mpg.de.ORCID http://orcid.org/0000-0001-5454-7755
Martijn S LuijsterburgDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. s.m.luijsterburg@lumc.nl.ORCID http://orcid.org/0000-0001-5796-6541
Leiden University Medical Center · NLMax Planck Institute for Multidisciplinary SciencesIo Therapeutics (United States) · USMax Planck Institute of Experimental Medicine · DEUniversitätsmedizin Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During transcription-coupled DNA repair (TCR), RNA polymerase II (Pol II) transitions from a transcriptionally active state to an arrested state that allows for removal of DNA lesions. This transition requires site-specific ubiquitylation of Pol II by the CRL4

Indexed as

RNA Polymerase IITranscription, GeneticDNADNA RepairExcision RepairLigasesReceptors, Antigen, T-CellUbiquitinationDNALigasesReceptors, Antigen, T-CellRNA Polymerase II

Identifiers

PMID38316879
PMCPMC10948364
OpenAlexW4391533249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.