Evidence map›Paper›PMID 38316806›Full record

ArticleScientific reports2024

Elevated body temperature is associated with depressive symptoms: results from the TemPredict Study.

Ashley E Mason, Patrick Kasl, Severine Soltani, Abigail Green, Wendy Hartogensis, Stephan Dilchert, Anoushka Chowdhary, Leena S Pandya, Chelsea J Siwik, Simmie L Foster and 5 more

Erratum issuedAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  13. Smart Ring in Clinical Medicine: A Systematic Review.Biomimetics (Basel, Switzerland) · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Ashley E MasonOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA, USA. ashley.mason@ucsf.edu.
Patrick KaslShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, San Diego, CA, USA.
Severine SoltaniShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, San Diego, CA, USA.
Abigail GreenNeurosciences Graduate Program, University of California San Diego, San Diego, CA, USA.
Wendy HartogensisOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA, USA.
Stephan DilchertDepartment of Management, Zicklin School of Business, Baruch College, The City University of New York, New York, NY, USA.
Anoushka ChowdharyDepartment of Psychology, The University of Arizona, Tucson, AZ, USA.
Leena S PandyaOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA, USA.
Chelsea J SiwikDepartment of Wellness and Preventative Medicine, Cleveland Clinic, Cleveland, OH, USA.
Simmie L FosterDepression Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.
Maren NyerDepression Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.
Christopher A LowryDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Charles L RaisonDepartment of Psychiatry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Frederick M Hecht *Osher Center for Integrative Health, University of California San Francisco, San Francisco, CA, USA.
Benjamin L Smarr *Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, San Diego, CA, USA.

Funding

Training Researchers in Clinical Integrative Medicine (TRIM) - NOSI supplementT32AT003997 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHELLEY R ADLER, MARIA T CHAO · 2007 to 2026
$6.6M
Graduate Training Program in BioinformaticsT32GM139790 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAFNA, VINEET, GAASTERLAND, THERESA · 2021 to 2025
$2.1M
Mentoring and Research in Integrative MedicineK24AT007827 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HECHT, FREDERICK M · 2013 to 2022
$1.8M
Medical Technology Enterprise Consortium MTEC-20-12-COVID19-D.-023NCCIH NIH HHS K24 AT007827NCCIH NIH HHS L30 AT011624NCCIH NIH HHS T32 AT003997NIGMS NIH HHS T32 GM139790Oura Health Oy 134650#StartSmall Foundation 7029991
6 · The paper itself

Abstract

Correlations between altered body temperature and depression have been reported in small samples; greater confidence in these associations would provide a rationale for further examining potential mechanisms of depression related to body temperature regulation. We sought to test the hypotheses that greater depression symptom severity is associated with (1) higher body temperature, (2) smaller differences between body temperature when awake versus asleep, and (3) lower diurnal body temperature amplitude. Data collected included both self-reported body temperature (using standard thermometers), wearable sensor-assessed distal body temperature (using an off-the-shelf wearable sensor that collected minute-level physiological data), and self-reported depressive symptoms from > 20,000 participants over the course of ~ 7 months as part of the TemPredict Study. Higher self-reported and wearable sensor-assessed body temperatures when awake were associated with greater depression symptom severity. Lower diurnal body temperature amplitude, computed using wearable sensor-assessed distal body temperature data, tended to be associated with greater depression symptom severity, though this association did not achieve statistical significance. These findings, drawn from a large sample, replicate and expand upon prior data pointing to body temperature alterations as potentially relevant factors in depression etiology and may hold implications for development of novel approaches to the treatment of major depressive disorder.

Indexed as

DepressionMajor Depressive DisorderBody TemperatureFeverHumansSelf Report

Identifiers

PMID38316806
PMCPMC10844227

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.