Evidence map›Paper›PMID 38316805›Full record

Trial reportScientific reports2024

Effect of ginger supplementation on the fecal microbiome in subjects with prior colorectal adenoma.

Ajay Prakash, Nathan Rubin, Christopher Staley, Guillaume Onyeaghala, Ya-Feng Wen, Aasma Shaukat, Ginger Milne, Robert J Straka, Timothy R Church, Anna Prizment

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ajay PrakashDivision of Hematology, Oncology, and Transplantation, University of Minnesota Medical School, Minneapolis, MN, USA. praka086@umn.edu.
Nathan RubinBiostatistics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Christopher StaleyDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.
Guillaume OnyeaghalaBiostatistics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Ya-Feng WenDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Aasma ShaukatNYU Langone Medical Center, New York, NY, USA.
Ginger MilneVanderbilt University Medical Center, Nashville, TN, USA.
Robert J StrakaDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Timothy R ChurchDivision of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, MN, USA.
Anna PrizmentDivision of Hematology, Oncology, and Transplantation, University of Minnesota Medical School, Minneapolis, MN, USA.
University of Minnesota · USUniversity of Minnesota Medical Center · USNYU Langone Health · USVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ginger has been associated with a decreased incidence of colorectal cancer (CRC) through reduction in inflammatory pathways and inhibition of tumor growth. Recent pre-clinical models have implicated changes in the gut microbiome as a possible mediator of the ginger effect on CRC. We hypothesized that, in adults previously diagnosed with a colorectal adenoma, ginger supplementation would alter the fecal microbiome in the direction consistent with its CRC-inhibitory effect. Sixty-eight adults were randomized to take either ginger or placebo daily for 6 weeks, with a 6-week washout and longitudinal stool collection throughout. We performed 16S rRNA sequencing and evaluated changes in overall microbial diversity and the relative abundances of pre-specified CRC-associated taxa using mixed-effects logistic regression. Ginger supplementation showed no significant effect on microbial community structure through alpha or beta diversity. Of 10 pre-specified CRC-associated taxa, there were significant decreases in the relative abundances of the genera Akkermansia (p < 0.001), Bacteroides (p = 0.018), and Ruminococcus (p = 0.013) after 6-week treatment with ginger compared to placebo. Ginger supplementation led to decreased abundances of Akkermansia and Bacteroides, which suggests that ginger may have an inhibitory effect on CRC-associated taxa. Overall, ginger supplementation appears to have a limited effect on gut microbiome in patients with colorectal adenomas.

Indexed as

AdenomaColorectal NeoplasmsMicrobiotaZingiber officinaleAdultDietary SupplementsFecesHumansRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID38316805
PMCPMC10844320
OpenAlexW4391527524

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.