Evidence map›Paper›PMID 38316771›Full record

ArticleNature communications2024

Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21.

Thomas Agius, Raffaella Emsley, Arnaud Lyon, Michael R MacArthur, Kevin Kiesworo, Anna Faivre, Louis Stavart, Martine Lambelet, David Legouis, Sophie de Seigneux and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

Thomas Agius *Department of Vascular Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.ORCID 0000-0001-6917-0831
Raffaella Emsley *Department of Vascular Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Arnaud LyonDepartment of Vascular Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.ORCID 0000-0003-1781-330X
Michael R MacArthurLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0003-3593-6995
Kevin KiesworoDepartment of Vascular Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Anna FaivreLaboratory of Nephrology, Department of Internal Medicine Specialties and Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.
Louis StavartTransplantation Center, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.ORCID 0009-0005-4072-0736
Martine LambeletDepartment of Vascular Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.ORCID 0000-0002-4239-2554
David LegouisLaboratory of Nephrology, Department of Internal Medicine Specialties and Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-2924-9737
Sophie de SeigneuxLaboratory of Nephrology, Department of Internal Medicine Specialties and Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-4243-366X
Déla GolshayanTransplantation Center, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.ORCID 0000-0001-5631-6096
Francois LazeyrasDepartment of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland.
Heidi YehTransplant Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
James F MarkmannTransplant Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2762-6535
Korkut UygunTransplant Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alejandro OcampoDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-3731-3647
Sarah J MitchellLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Florent AllagnatDepartment of Vascular Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.ORCID 0000-0001-6528-679X
Sébastien DégliseDepartment of Vascular Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Alban LongchampDepartment of Vascular Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland. alban.longchamp@chuv.ch.ORCID 0000-0002-1743-4935
University Hospital of Lausanne · CHHarvard University · USUniversity of Geneva · CHUniversity of Lausanne · CHPrinceton University · US

Funding

Mendez National Institute of Transplantation Foundation (MNITF) NASchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) SNSF-310030_176158Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) SNSF PZ00P3-185927
6 · The paper itself

Abstract

Dietary restriction promotes resistance to surgical stress in multiple organisms. Counterintuitively, current medical protocols recommend short-term carbohydrate-rich drinks (carbohydrate loading) prior to surgery, part of a multimodal perioperative care pathway designed to enhance surgical recovery. Despite widespread clinical use, preclinical and mechanistic studies on carbohydrate loading in surgical contexts are lacking. Here we demonstrate in ad libitum-fed mice that liquid carbohydrate loading for one week drives reductions in solid food intake, while nearly doubling total caloric intake. Similarly, in humans, simple carbohydrate intake is inversely correlated with dietary protein intake. Carbohydrate loading-induced protein dilution increases expression of hepatic fibroblast growth factor 21 (FGF21) independent of caloric intake, resulting in protection in two models of surgical stress: renal and hepatic ischemia-reperfusion injury. The protection is consistent across male, female, and aged mice. In vivo, amino acid add-back or genetic FGF21 deletion blocks carbohydrate loading-mediated protection from ischemia-reperfusion injury. Finally, carbohydrate loading induction of FGF21 is associated with the induction of the canonical integrated stress response (ATF3/4, NF-kB), and oxidative metabolism (PPARγ). Together, these data support carbohydrate loading drinks prior to surgery and reveal an essential role of protein dilution via FGF21.

Indexed as

Diet, Carbohydrate LoadingFibroblast Growth FactorsReperfusion InjurySurgical Procedures, OperativeAnimalsDietary CarbohydratesDietary ProteinsFemaleHumansLiverMaleMiceMice, Inbred C57BLDietary CarbohydratesDietary Proteinsfibroblast growth factor 21Fibroblast Growth Factors

Identifiers

PMID38316771
PMCPMC10844297
OpenAlexW4391543259

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.