Evidence map›Paper›PMID 38316739›Full record

ArticleEnvironmental science and pollution research international2024

Is the reliability of wastewater-based epidemiology affected by season? Comparative analysis with pharmaceuticals prescriptions.

Marco Carnevale Miino, Tomáš Macsek, Taťána Halešová, Tomáš Chorazy, Petr Hlavínek

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Article in Environmental science and pollution research international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marco Carnevale MiinoAdMaS Research Centre, Faculty of Civil Engineering, Brno University of Technology, Purkyňova 651/139, 612 00, Brno, Czech Republic. marco.carnevalemiino@uninsubria.it.ORCID http://orcid.org/0000-0003-3669-1635
Tomáš MacsekAdMaS Research Centre, Faculty of Civil Engineering, Brno University of Technology, Purkyňova 651/139, 612 00, Brno, Czech Republic.ORCID http://orcid.org/0000-0002-7919-0593
Taťána HalešováAdMaS Research Centre, Faculty of Civil Engineering, Brno University of Technology, Purkyňova 651/139, 612 00, Brno, Czech Republic.
Tomáš ChorazyAdMaS Research Centre, Faculty of Civil Engineering, Brno University of Technology, Purkyňova 651/139, 612 00, Brno, Czech Republic.ORCID http://orcid.org/0000-0002-4778-0708
Petr HlavínekAdMaS Research Centre, Faculty of Civil Engineering, Brno University of Technology, Purkyňova 651/139, 612 00, Brno, Czech Republic.ORCID http://orcid.org/0000-0001-7135-8075

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wastewater-based epidemiology (WBE) has been already proposed by several authors for estimating the consumption of drugs, mainly the illicit ones. However, not much information is available about the actual reliability of this tool given the absence of comparison with the actual consumption. This work aims to evaluate the reliability of the WBE as a tool for estimating the consumption of pharmaceuticals in urban area. Measured consumption back-calculated with a WBE approach was compared with prescription of pharmaceutical products as "control." Moreover, seasonal influence on (i) pharmaceutical consumption, (ii) load of pharmaceutical products in the sewer system, and (iii) reliability of WBE was evaluated. Ciprofloxacin, sulfamethoxazole, metoprolol, carbamazepine, and citalopram were estimated by WBE with a difference respect to the "control" value lower than 0.2 order of magnitude while only trimethoprim and sotalol exceeded the 0.5 order of magnitude of difference but below the 1 order of magnitude. Sedatives were the best represented by WBE (on average 0.15 order of magnitude of difference compared to prescription data). However, further studies are suggested to fully estimate the influence of the type of APs on the reliability of the WBE. Seasonal patterns were found for the load of ciprofloxacin in the sewer and for the consumption of sulfamethoxazole and trimethoprim by population but seasonal changes did not have a significant impact (p > 0.05) on the reliability of WBE. Despite some gaps remained to optimize the reliability of the tool, WBE can be considered a valid method to estimate the consumption of prescribed drugs from the analysis of the sewer system.

Indexed as

Wastewater-Based Epidemiological MonitoringWater Pollutants, ChemicalCiprofloxacinPharmaceutical PreparationsReproducibility of ResultsSeasonsSulfamethoxazoleTrimethoprimWastewaterCiprofloxacinPharmaceutical PreparationsSulfamethoxazoleTrimethoprimWastewaterWater Pollutants, ChemicalDrug consumptionEmerging contaminantsPharmaceutical productsSeasonal patternsWastewater treatment plantWBE

Identifiers

PMID38316739

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.