ArticleJournal of cancer survivorship : research and practice2025
Pre-treatment fertility preservation and post-treatment reproduction in long-term survivors of adolescent and young adult (AYA) cancer.
Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Longitudinal Ovarian Reserve in Female Adolescents/Young Adults With Lymphoma: A Report From Children's Oncology Group Study ALTE11C1.Pediatric blood & cancer · 2026Article
- Counseling and use of surrogacy among cancer survivors (CUSACS).Journal of cancer survivorship : research and practice · 2026Article
- Perceived Versus Demonstrated Oncofertility Knowledge Among Oncology Providers.Journal of adolescent and young adult oncology · 2026Article
- Double jeopardy: howFrontiers in cell and developmental biology · 2026Review
- Lived experiences of sexual wellbeing and psychosexual needs among adolescents and young adults with sarcoma: a qualitative study.Frontiers in psychology · 2026Article
- Editorial: Adverse and toxic effects of childhood cancer treatments, volume II.Frontiers in oncology · 2025Article
- Fertility preservation options at cancer diagnosis; classifying use and decision-making in the United States.Expert review of endocrinology & metabolism · 2025Review
- Sendai virus-mediated RNA delivery restores fertility to congenital and chemotherapy-induced infertile female mice.PNAS nexus · 2024Article
- Article
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Authors and funding
16 authors.
Funding
Abstract
purposeTo describe recall of fertility-related consultations and cryopreservation and to examine reproductive goals and reproduction post-treatment in long-term survivors of adolescent and young adult (AYA) (age, 18-39 years) cancer.
methodsThis study included n = 1457 male and n = 2112 female long-term survivors (M
resultsMost male survivors (72.7%) recalled fertility-related consultations and 22.6% completed sperm cryopreservation. Younger age (OR = 2.8; 95%CI [2.2-3.6]), not having children (OR = 5.0; 95%CI [3.2-7.7]), testicular cancer or lymphoma/leukemia (OR = 2.8/2.5 relative to "others"), and more intense treatments (OR = 1.5; 95%CI [1.1-2.0]) were associated with higher cryopreservation rates. Time since diagnosis had no effect. Of men who cryopreserved, 12.1% utilized assisted reproductive technologies (ART). Most men (88.5%) felt their diagnosis did not affect their reproductive goals, but 7.6% wanted no (additional) children due to cancer. Half of female survivors (55.4%; n = 1171) recalled fertility-related consultations. Rates of cryopreservation were very low (3.6%), but increased after 2013 when oocyte cryopreservation became non-experimental. Of women who cryopreserved, 13.2% successfully utilized ART. Most women (74.8%) experienced no effects of cancer on reproductive goals, but 17.8% wanted no (additional) children due to cancer.
conclusionsCryopreservation in men varied by patient/clinical factors and was very low in women, but data of more recently treated females are needed. Utilizing cryopreserved material through ART was rare, which questions its cost-effectiveness, but it may enhance survivors' well-being. IMPLICATIONS FOR CANCER SURVIVORS: The extent to which cryopreservation positively affects survivors' well-being remains to be tested. Moreover, effects of cancer on reproductive goals require further attention, especially in women who refrain from having children due to cancer.
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