Evidence map›Paper›PMID 38316588›Full record

ArticleBMJ open2024

Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonisation (OPSiP trial): study protocol for a double-blind parallel group randomised placebo trial.

Kelly Hayes, Patricia Janssen, Beth A Payne, Cecilia Jevitt, Will Johnston, Patricia Johnson, Michelle Butler

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03407157 (Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonization), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03407157 phase3unknown statusnot on this map

Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonization

TypeinterventionalSponsorUniversity of British ColumbiaRan2020 to 2024Enrolled168ConditionsGroup B Streptococcus Carrier in ChildbirthArmsProbiotic supplementation, Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Kelly HayesBCCHR, The University of British Columbia, Vancouver, British Columbia, Canada kelly.hayes@bcchr.ca.ORCID 0009-0009-7551-8211
Patricia JanssenThe University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-4178-1195
Beth A PaynePaediatrics, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0001-6150-8703
Cecilia JevittThe University of British Columbia, Vancouver, British Columbia, Canada.
Will JohnstonThe University of British Columbia, Vancouver, British Columbia, Canada.
Patricia JohnsonDublin City University, Dublin, Ireland.
Michelle ButlerFaculty of Science and Health, Dublin City University, Dublin, Ireland.ORCID 0000-0002-8336-0890
University of British Columbia · CADublin City University · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMETHODS AND ANALYSIS: This double-blind parallel group randomised trial aims to recruit 450 pregnant participants in Vancouver, BC, Canada and will compare GBS colonisation rates in those who have received a daily oral dose of three strains of probiotics with those who have received a placebo. The primary outcome will be GBS colonisation status, measured using a vaginal/rectal swab obtained between 35 weeks' gestation and delivery. Secondary outcomes will include maternal antibiotic exposure and urogenital infections. Analysis will be on an intention-to-treat basis. PATIENT OR PUBLIC INVOLVEMENT: There was no patient or public involvement in the design of the study protocol. ETHICS AND DISSEMINATION: This study protocol received ethics approval from the University of British Columbia's Clinical Research Ethics Board, Dublin City University and Health Canada. Findings will be presented at research rounds, conferences and in peer-reviewed publications. TRIAL REGISTRATION NUMBER: NCT03407157.

Indexed as

Pregnancy Complications, InfectiousProbioticsStreptococcal InfectionsAnti-Bacterial AgentsCanadaFemaleHumansInfant, NewbornPregnancyRandomized Controlled Trials as TopicStreptococcus agalactiaeAnti-Bacterial AgentsBACTERIOLOGYClinical TrialInfections diseaseINFECTIOUS DISEASESMicrobiologyNEONATOLOGYOBSTETRICSPregnancyprobioticsStreptococcus agalactiae

Identifiers

PMID38316588
PMCPMC10860072
OpenAlexW4391572715

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.