ArticleProceedings of the National Academy of Sciences of the United States of America2024
Prebiotic access to enantioenriched amino acids via peptide-mediated transamination reactions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- A Nonenzymatic Analogue of the Biosynthesis of Pyridoxal Vitamers.Journal of the American Chemical Society · 2026Article
- Kinetic resolution of amino acids by phosphine oxide catalyzed enantioselective esterification.Nature communications · 2026Article
- Conversion of pyridoxal to pyridoxamine with NHThe FEBS journal · 2025Article
- Autocatalytic symmetry breaking and chiral amplification in a feedback network combining amino acid synthesis and ligation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Pinpointing Conditions for a Metabolic Origin of Life: Underlying Mechanisms and the Role of Coenzymes.Accounts of chemical research · 2024Article
- Coenzymes in a pre-enzymatic metabolism.Science advances · 2024Review
- Amino acid analogues provide multiple plausible pathways to prebiotic peptides.Journal of the Royal Society, Interface · 2024Review
- Selective Generation of Aldimine and Ketimine Tautomers of the Schiff Base Condensates of Amino Acids with Imidazole Aldehydes or of Imidazole Methanamines with Pyruvates-Isomeric Control with 2- vs. 4-Substituted Imidazoles.Molecules (Basel, Switzerland) · 2024Article
- Profile of Donna G. Blackmond.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The kinetic resolution of racemic amino acids mediated by dipeptides and pyridoxal provides a prebiotically plausible route to enantioenriched proteinogenic amino acids. The enzymatic transamination cycles that are key to modern biochemical formation of enantiopure amino acids may have evolved from this half of the reversible reaction couple. Kinetic resolution of racemic precursors emerges as a general route to enantioenrichment under prebiotic conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.