ArticleBlood transfusion = Trasfusione del sangue2025
Red blood cell transfusion in patients undergoing elective primary glioblastoma resection.
Article in Blood transfusion = Trasfusione del sangue, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Fluid-therapy for Brain Surgery: A Narrative Review.Turkish journal of anaesthesiology and reanimation · 2026Article
- Preoperative embolization for glioblastoma surgery: A scoping review.Surgical neurology international · 2026Review
- Assessment of natural killer cell subpopulations in pediatric patients with transfusion-dependent β-thalassemia major.Clinical and experimental pediatrics · 2025Article
- Efficiency in packed red blood management for brain tumor resection: multicenter prospective cohort study (TScoreBTR).Blood transfusion = Trasfusione del sangueObservational
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14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundRed blood cell (RBC) transfusion in patients undergoing major elective cranial surgery is associated with increased postoperative morbidity and mortality. This study aims to identify the clinical outcome of transfused glioblastoma patients undergoing primary surgical tumor resection and identify risk factors for RBC transfusion. MATERIAL AND
methodsBetween 2009 and 2019, 406 patients underwent elective primary glioblastoma resection. For multivariate analysis to assess risk factors for RBC transfusion, logistic regression was conducted. The impact of RBC transfusion on overall survival was assessed using Kaplan-Meier analysis.
resultsIn total, 36 (8.9%) patients received RBC transfusion. Preoperative anemia rate was significantly higher in transfused patients compared to patients without RBC transfusion (33.3 vs 6.5%; p<0.0001). Postoperative complications as well as hospital length of stay (LOS) (p<0.0001) were significantly increased in transfused patients compared to non-transfused patients. After multivariate analysis, risk factors for RBC transfusion were preoperative anemia (p<0.0001), intraoperative blood loss (p<0.0001), female gender (p=0.0056) and radiation (p=0.0064). Kaplan-Meier curves revealed that RBC transfusion and being elderly (age ≥75 years) were relevant for overall survival. DISCUSSION: RBC transfusion is associated with increased postoperative morbidity and mortality in patients undergoing elective primary glioblastoma resection. Preoperative anemia and intraoperative blood loss are major risk factors for RBC transfusion. Preoperative anemia management and blood conservation strategies are crucial in patients undergoing elective primary glioblastoma resection.
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