Evidence map›Paper›PMID 38315500›Full record

ArticleChemical research in toxicology2024

Association of Urinary N7-(1-hydroxyl-3-buten-1-yl) Guanine (EB-GII) Adducts and Butadiene-Mercapturic Acids with Lung Cancer Development in Cigarette Smokers.

Caitlin C Jokipii Krueger, Sungshim L Park, Yesha Patel, Daniel O Stram, Melinda Aldrich, Qiuyin Cai, Natalia Y Tretyakova

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Caitlin C Jokipii KruegerMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0002-5072-6614
Sungshim L ParkEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, United States.
Yesha PatelDepartment of Preventative Medicine, School of Medicine, University of Southern California, Los Angeles, California 90089, United States.
Daniel O StramDepartment of Preventative Medicine, School of Medicine, University of Southern California, Los Angeles, California 90089, United States.
Melinda AldrichDepartment of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
Qiuyin CaiDepartment of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
Natalia Y TretyakovaMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0002-0621-6860
University of Minnesota · USUniversity of Southern California · USVanderbilt University · USUniversity of Hawaiʻi at Mānoa · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Untargeted Adductomics to Characterize Ethnic Differences in the Exposome of SmokersP01CA138338 · NCI · UNIVERSITY OF MINNESOTA · PI STEPHEN S HECHT · 2010 to 2026
$33.4M
Southern Community Cohort StudyU01CA202979 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., SHRUBSOLE, MARTHA J. · 2016 to 2025
$22.0M
DNA Cross-Linking By DiepoxybutaneR01CA100670 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TRETYAKOVA, NATALIA Y · 2003 to 2021
$3.5M
NCI NIH HHS P01 CA138338NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA100670NCI NIH HHS U01 CA202979
6 · The paper itself

Abstract

Approximately 10% of smokers will develop lung cancer. Sensitive predictive biomarkers are needed to identify susceptible individuals. 1,3-Butadiene (BD) is among the most abundant tobacco smoke carcinogens. BD is metabolically activated to 3,4-epoxy-1-butene (EB), which is detoxified via the glutathione conjugation/mercapturic acid pathway to form monohydroxybutenyl mercapturic acid (MHBMA) and dihydroxybutyl mercapturic acid (DHBMA). Alternatively, EB can react with guanine nucleobases of DNA to form N7-(1-hydroxyl-3-buten-1-yl) guanine (EB-GII) adducts. We employed isotope dilution LC/ESI-HRMS/MS methodologies to quantify MHBMA, DHBMA, and EB-GII in urine of smokers who developed lung cancer (

Indexed as

Lung NeoplasmsTobacco ProductsAcetylcysteineBiomarkersButadienesDNA AdductsGuanineHumansSmokers1,3-butadieneAcetylcysteineBiomarkersButadienesDNA AdductsGuanine

Identifiers

PMID38315500
PMCPMC11491053
OpenAlexW4391543175

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.