Evidence map›Paper›PMID 38315417›Full record

ArticleApplied microbiology and biotechnology2024

Novel anti-inflammatory diketopiperazine alkaloids from the marine-derived fungus Penicillium brasilianum.

Ya-Hui Zhang, Hui-Fang Du, Yun-Feng Liu, Fei Cao, Du-Qiang Luo, Chang-Yun Wang

Abstract read
In one paragraph

Article in Applied microbiology and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Spiro-Linked Polyketides from Cultures ofJournal of natural products · 2026
    Article
  2. Review
  3. Article
  4. Marine natural products.Natural product reports · 2026
    Review
  5. Isolation of Three New Diketopiperazine Alkaloids fromMolecules (Basel, Switzerland) · 2026
    Article
  6. Article
  7. Bisindole Compounds-Synthesis and Medicinal Properties.Antibiotics (Basel, Switzerland) · 2024
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ya-Hui ZhangCollege of Life Sciences, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, Hebei University, Baoding, 071002, China.
Hui-Fang DuCollege of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China.
Yun-Feng LiuCollege of Life Sciences, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, Hebei University, Baoding, 071002, China.
Fei CaoCollege of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China. caofei542927001@163.com.ORCID http://orcid.org/0000-0002-5676-3176
Du-Qiang LuoCollege of Life Sciences, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, Hebei University, Baoding, 071002, China. duqiangluo@hbu.edu.cn.
Chang-Yun WangLaboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, 266003, China. changyun@ouc.edu.cn.

Funding

National Natural Science Foundation of China No. 41830535Postdoctoral research grant of Hebei University No. 703202305Shandong Provincial Natural Science Foundation (Major Basic Research Projects) ZR2019ZD18S&T Program of Hebei No. 21323202Dthe Major Project of Qingdao Marine Science and Technology Center No. 2022QNLM030003-1
6 · The paper itself

Abstract

Diketopiperazine alkaloids have proven the most abundant heterocyclic alkaloids up to now, which usually process diverse scaffolds and rich biological activities. In our search for bioactive diketopiperazine alkaloids from marine-derived fungi, two novel diketopiperazine alkaloids, penipiperazine A (1) and its biogenetically related new metabolite (2), together with a known analogue neofipiperzine C (3), were obtained from the strain Penicillium brasilianum. Their planar structures and absolute configurations were elucidated by extensive spectroscopic analyses,

Indexed as

AlkaloidsPenicilliumAnti-Inflammatory AgentsCytokinesDiketopiperazinesFungiIndole AlkaloidsIndolesLipopolysaccharidesMolecular StructureAlkaloidsAnti-Inflammatory AgentsCytokinesDiketopiperazinesIndole AlkaloidsIndolesLipopolysaccharidesAnti-inflammatory activityDiketopiperazine alkaloidMarfey’s methodMarine-derived fungusPenicillium brasilianumQuantum chemical calculation

Identifiers

PMID38315417
PMCPMC10844341

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.