Evidence map›Paper›PMID 38315346›Full record

ArticleCardiovascular toxicology2024

Fermented Rooibos tea (Aspalathus linearis) Ameliorates Sodium Fluoride-Induced Cardiorenal Toxicity, Oxidative Stress, and Inflammation via Modulation of NF-κB/IκB/IκKB Signaling Pathway in Wistar Rats.

Olawale Razaq Ajuwon, Toyosi Abiodun Adeleke, Basiru Olaitan Ajiboye, Akeem Olalekan Lawal, Ibukun Folorunso, Bartholomew Brai, Fisayo Abraham Bamisaye, John Adeolu Falode, Ikenna Maximillian Odoh, Kabirat Iyabode Adegbite and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Cardiovascular toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Olawale Razaq AjuwonDepartment of Biochemistry, Federal University, Oye-Ekiti, Oye-Are Road, P.M.B. 373, Oye-Ekiti, 371104, Ekiti State, Nigeria. olawale.ajuwon@fuoye.edu.ng.
Toyosi Abiodun AdelekeDepartment of Biochemistry, Federal University, Oye-Ekiti, Oye-Are Road, P.M.B. 373, Oye-Ekiti, 371104, Ekiti State, Nigeria.
Basiru Olaitan AjiboyeDepartment of Biochemistry, Federal University, Oye-Ekiti, Oye-Are Road, P.M.B. 373, Oye-Ekiti, 371104, Ekiti State, Nigeria.
Akeem Olalekan LawalDepartment of Biochemistry, Federal University of Technology, Akure, P.M.B. 704, Akure, Ondo State, Nigeria.
Ibukun FolorunsoDepartment of Biochemistry, Federal University of Technology, Akure, P.M.B. 704, Akure, Ondo State, Nigeria.
Bartholomew BraiDepartment of Biochemistry, Federal University, Oye-Ekiti, Oye-Are Road, P.M.B. 373, Oye-Ekiti, 371104, Ekiti State, Nigeria.
Fisayo Abraham BamisayeDepartment of Biochemistry, Federal University, Oye-Ekiti, Oye-Are Road, P.M.B. 373, Oye-Ekiti, 371104, Ekiti State, Nigeria.
John Adeolu FalodeDepartment of Biochemistry, Federal University, Oye-Ekiti, Oye-Are Road, P.M.B. 373, Oye-Ekiti, 371104, Ekiti State, Nigeria.
Ikenna Maximillian OdohDepartment of Biochemistry, Federal University, Oye-Ekiti, Oye-Are Road, P.M.B. 373, Oye-Ekiti, 371104, Ekiti State, Nigeria.
Kabirat Iyabode AdegbiteDepartment of Environmental Health Science, College of Basic Medical and Health Sciences, Fountain University, Osogbo, P.M.B. 4491, Osogbo, Osun State, Nigeria.
Oluwasayo Bosede AdegokeDepartment of Chemical Pathology, Ekiti State University, Ado-Ekiti, Ekiti State, Nigeria.
Federal University Oye Ekiti · NGFederal University of Technology · NGEkiti State University · NGFountain University · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High dose of fluoride intake is associated with toxic effects on kidney and cardiac tissues. This study evaluated the potential protective effect of fermented rooibos tea (RTE) on sodium fluoride (NaF)-induced cardiorenal toxicity in rats. Male Wistar rats (n = 56) were randomly allocated into one of seven equal groups: control, NaF (100 mg/kg orally), NaF + RTE (2%, w/v), NaF + RTE (4%, w/v), NaF + lisinopril (10 mg/kg orally), 2% RTE, and 4% RTE. The experiment lasted for 14 days and RTE was administered to the rats as their sole source of drinking fluid. NaF induced cardiorenal toxicity indicated by elevated level of urea, creatinine, LDH, creatinine kinase-MB, and cardiac troponin I in the serum, accompanied by altered histopathology of the kidney and heart. Furthermore, levels of H

Indexed as

AspalathusSodium FluorideAnimalsCreatinineHydrogen PeroxideInflammationMaleNF-kappa BOxidative StressRatsRats, WistarRNA, MessengerSignal TransductionTeaCreatinineHydrogen PeroxideNF-kappa BRNA, MessengerSodium FluorideTeaCardiorenal toxicityInflammationOxidative stressRooibosSodium fluoride

Identifiers

PMID38315346
OpenAlexW4391540413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.