Evidence map›Paper›PMID 38315327›Full record

ArticleCanadian journal of public health = Revue canadienne de sante publique2024

Breast (female), colorectal, and lung cancer survival in people with intellectual or developmental disabilities: A population-based retrospective cohort study.

Rebecca L Hansford, Hélène Ouellette-Kuntz, Rebecca Griffiths, Julie Hallet, Kathleen Decker, David E Dawe, Mark Kristjanson, Virginie Cobigo, Shahin Shooshtari, Morgan Stirling and 4 more

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In one paragraph

Article in Canadian journal of public health = Revue canadienne de sante publique, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rebecca L HansfordDepartment of Public Health Sciences, Queen's University, Kingston, ON, Canada.
Hélène Ouellette-KuntzDepartment of Public Health Sciences, Queen's University, Kingston, ON, Canada.
Rebecca GriffithsICES, Toronto, ON, Canada.
Julie HalletICES, Toronto, ON, Canada.
Kathleen DeckerDepartment of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
David E DaweCancerCare Manitoba, Winnipeg, MB, Canada.
Mark KristjansonDepartment of Family Medicine, University of Manitoba, Winnipeg, MB, Canada.
Virginie CobigoICES, Toronto, ON, Canada.
Shahin ShooshtariDepartment of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Morgan StirlingDepartment of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Christine KellyDepartment of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Marni BrownellDepartment of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Donna TurnerDepartment of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Alyson MaharICES, Toronto, ON, Canada. alyson.mahar@queensu.ca.ORCID 0000-0002-6862-3760

Funding

CIHR 162130
6 · The paper itself

Abstract

objectivesCancer is a leading cause of death among people living with intellectual or developmental disabilities (IDD). There is little empirical evidence documenting survival or comparing outcomes to those without IDD. This study investigated the association between IDD and cancer survival among adults with breast (female), colorectal, or lung cancer.

methodsA population-based retrospective cohort study was conducted in Ontario, Canada, with routinely collected data. Patients with breast, colorectal, or lung cancer were included (2007‒2019). IDD status before cancer was determined using an established administrative data algorithm. The outcomes of interest included death from any cause and death from cancer. Cox proportional hazards models and competing events analyses using multivariable cause-specific hazards regression were completed. Analyses were stratified by cancer type. Interactions with age, sex, and stage at diagnosis, as well as sensitivity analyses, were completed.

resultsThe final cohorts included 123,695 breast, 98,809 colorectal, and 116,232 lung cancer patients. Individuals with IDD experienced significantly worse survival than those without IDD. The adjusted hazard ratios of all-cause death were 2.74 (95% CI 2.41‒3.12), 2.42 (95% CI 2.18‒2.68), and 1.49 (95% CI 1.34‒1.66) times higher for breast, colorectal, and lung cancer patients with IDD relative to those without. These findings were consistent for cancer-specific deaths. With few exceptions, worse survival for people with IDD persisted regardless of stage at diagnosis.

conclusionPeople with IDD experienced worse cancer survival than those without IDD. Identifying and intervening on the factors and structures responsible for survival disparities is imperative.

Indexed as

Colorectal NeoplasmsLung NeoplasmsAdultChildDevelopmental DisabilitiesFemaleHumansOntarioRetrospective StudiesAdministrative dataCancer survivalEquityIntellectual or developmental disabilityPopulation-based studyRetrospective cohort study

Identifiers

PMID38315327
PMCPMC11027730

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.