Evidence map›Paper›PMID 38315192›Full record

ReviewWorld journal of urology2024

The role of oral antioxidants in the improvement of sperm parameters in infertile men.

Georgios Kallinikas, James N Tsoporis, Georgios Haronis, Anastasios Zarkadas, Dimitrios Bozios, Vassilios Konstantinopoulos, Diomidis Kozyrakis, Despoina Mitiliniou, Evangelos Rodinos, Athanasios Filios and 2 more

Abstract readReview
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In one paragraph

Review in World journal of urology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Georgios KallinikasDepartment of Urology, General hospital Konstantopouleio-Patision, N Ionia, Attika, Greece.
James N TsoporisSt. Michael's Hospital, Unity Health Toronto, Li Ka Shing Knowledge Institute, Keenan Research Centre for Biomedical Science, 30 Bond St., Toronto, ON, M5B 1W8, Canada. jimtsoporis@sympatico.ca.ORCID http://orcid.org/0000-0003-0570-7542
Georgios HaronisDepartment of Urology, General hospital Konstantopouleio-Patision, N Ionia, Attika, Greece.
Anastasios ZarkadasDepartment of Urology, General hospital Konstantopouleio-Patision, N Ionia, Attika, Greece.
Dimitrios BoziosDepartment of Urology, General hospital Konstantopouleio-Patision, N Ionia, Attika, Greece.
Vassilios KonstantinopoulosDepartment of Urology, General hospital Konstantopouleio-Patision, N Ionia, Attika, Greece.
Diomidis KozyrakisDepartment of Urology, General hospital Konstantopouleio-Patision, N Ionia, Attika, Greece.
Despoina MitiliniouDepartment of Urology, General hospital Konstantopouleio-Patision, N Ionia, Attika, Greece.
Evangelos RodinosDepartment of Urology, General hospital Konstantopouleio-Patision, N Ionia, Attika, Greece.
Athanasios FiliosDepartment of Urology, General hospital Konstantopouleio-Patision, N Ionia, Attika, Greece.
Panagiotis FiliosDepartment of Urology, General hospital Konstantopouleio-Patision, N Ionia, Attika, Greece.
Gerasimos VlassopoulosDepartment of Urology, General hospital Konstantopouleio-Patision, N Ionia, Attika, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA variety of pathologic conditions may increase oxidative stress in semen resulting in structural modifications to spermozoa's plasma membrane that interfere with sperm motility, morphology, and count. Antioxidants are currently being marketed to treat male infertility. In semen, antioxidants may decrease oxidative stress and potentially improve sperm parameters. In this narrative, mini-review we evaluated the effectiveness of antioxidants in infertility.

methodsThis mini-review of the current literature has been carried out through searching of the PubMed and Google scholar databases. RESULTS AND

conclusionsThe literature review suggests that there is evidence that oral antioxidants such as selenium, carnitine, zinc, coenzymeQ10, vitamins E and C, etc. alone or in combinations, improve sperm count, motility, morphology as well as pregnancy rates in infertile men with idiopathic oligoasthenospermia. Unfortunately, most of these studies are poorly designed, limited by sample size, varying in dosage, differing in primary end points, and most notably lacking live birth data. Importantly, large randomized, well-designed, placebo-controlled trials are needed.

Indexed as

AntioxidantsInfertility, MaleFemaleHumansMalePregnancySemenSpermatozoaSperm CountSperm MotilityAntioxidantsAntioxidantsMale infertilityOxidative stressSperm parameters

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.