Evidence map›Paper›PMID 38315141›Full record

ArticleHepatology communications2024

Problematic alcohol use and its impact on liver disease quality of life in a multicenter study of patients with cirrhosis.

Jeremy W Luk, Derek D Satre, Ramsey Cheung, Robert J Wong, Alexander Monto, Jennifer Y Chen, Steven L Batki, Michael J Ostacher, Hannah R Snyder, Amy M Shui and 3 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hepatology communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05191446 (Impact of the Coronavirus 2019), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05191446 naactive not recruitingnot on this map

Impact of the Coronavirus 2019 (COVID-19) Pandemic on Patient Outcomes, Telehealth Care Delivery, and Treatment for Unhealthy Alcohol Use in Vulnerable Patients With Advanced Liver Disease Across Two Healthcare Systems

TypeinterventionalSponsorUniversity of California, San FranciscoRan2022 to 2026Enrolled180ConditionsLiver Diseases, Alcohol Use DisorderArmsStepped alcohol intervention (SAT) to reduce unhealthy alcohol use, Usual Care (UC)
3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jeremy W LukOffice of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.ORCID 0000-0002-9061-1555
Derek D SatreDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.ORCID 0000-0002-4228-1504
Ramsey CheungDepartment of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.
Robert J WongDepartment of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.
Alexander MontoDivision of Gastroenterology and Hepatology, Veterans Affairs San Francisco Health Care System, San Francisco, California, USA.
Jennifer Y ChenDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Steven L BatkiDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Michael J OstacherDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.
Hannah R SnyderDepartment of Family and Community Medicine, University of California, San Francisco, California, USA.
Amy M ShuiDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Meimei LiaoGastroenterology Section, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Christina G HaightDivision of Gastroenterology and Hepatology, Veterans Affairs San Francisco Health Care System, San Francisco, California, USA.
Mandana KhaliliDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0001-9178-9139

Funding

Impact of the COVID-19 pandemic on patient outcomes, telehealth care delivery, and treatment for unhealthy alcohol use in vulnerable patients with advanced liver disease across two healthcare systemsR01AA029312 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHALILI, MANDANA, SATRE, DEREK D · 2021 to 2025
$3.5M
Mentoring Multidisciplinary Patient-Oriented Research in Viral HepatitisK24AA022523 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHALILI, MANDANA · 2013 to 2023
$1.9M
Mentoring alcohol use intervention research in HIV health care settingsK24AA025703 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Derek D Satre · 2018 to 2026
$1.8M
NIAAA NIH HHS K24 AA022523NIAAA NIH HHS K24 AA025703NIAAA NIH HHS R01 AA029312
6 · The paper itself

Abstract

backgroundManagement of cirrhosis is challenging and has been complicated by the COVID-19 pandemic due to decreased access to care, increased psychological distress, and alcohol misuse. Recently, The National Institute on Alcohol Abuse and Alcoholism has broadened the definition of recovery from alcohol use disorder to include quality of life (QoL) as an indicator of recovery. This study examined the associations of alcohol-associated cirrhosis etiology and problematic drinking with liver disease QoL (LDQoL).

methodsPatients with cirrhosis (N=329) were recruited from 3 sites (63% from 2 Veterans Affairs Health Care Systems and 37% from 1 safety net hospital) serving populations that are economically or socially marginalized. Cirrhosis etiology was ascertained by chart review of medical records. Problematic drinking was defined by ≥8 on the Alcohol Use Disorders Identification Test. Multivariable general linear modeling adjusting for age, sex, race/ethnicity, site, pandemic-related stress, and history of anxiety/depressive disorder were conducted. Sensitivity analyses further adjusted for indicators of liver disease severity.

resultsParticipants were on average 64.6 years old, 17% female, 58% non-White, 44% with alcohol-associated cirrhosis, and 17% with problematic drinking. Problematic drinking was significantly associated with worse LDQoL scores in the overall scale and in the memory/concentration and health distress subscales. These associations remained significant after adjusting for indicators of liver disease severity, including Model for End-Stage Liver Disease-Sodium score and decompensated cirrhosis status.

conclusionsAmong patients with cirrhosis, problematic drinking was associated with worse LDQoL, especially in the domains of memory/concentration and health distress. Assessment and awareness of cognitive deficits and negative emotionality within the context of cirrhosis and problematic drinking may help clinicians provide better integrated care for this population.

Indexed as

AlcoholismEnd Stage Liver DiseaseEthanolFemaleHumansLiver CirrhosisMaleMiddle AgedPandemicsQuality of LifeSeverity of Illness IndexEthanol

Identifiers

PMID38315141
PMCPMC10843394

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.