Evidence map›Paper›PMID 38315113›Full record

ArticleACS nano2024

Optical Microscopy Using the Faraday Effect Reveals

Maneea Eizadi Sharifabad, Rémy Soucaille, Xuyiling Wang, Michael Rotherham, Tom Loughran, James Everett, David Cabrera, Ying Yang, Robert Hicken, Neil Telling

Abstract read
In one paragraph

Article in ACS nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maneea Eizadi SharifabadSchool of Pharmacy and Bioengineering, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Stoke-on-Trent ST4 7QB, United Kingdom.
Rémy SoucailleDepartment of Physics and Astronomy, University of Exeter, Stocker Road, Exeter EX4 4QL, United Kingdom.
Xuyiling WangSchool of Pharmacy and Bioengineering, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Stoke-on-Trent ST4 7QB, United Kingdom.ORCID 0009-0000-5614-0772
Michael RotherhamSchool of Pharmacy and Bioengineering, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Stoke-on-Trent ST4 7QB, United Kingdom.ORCID 0000-0002-9297-7681
Tom LoughranDepartment of Physics and Astronomy, University of Exeter, Stocker Road, Exeter EX4 4QL, United Kingdom.
James EverettSchool of Pharmacy and Bioengineering, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Stoke-on-Trent ST4 7QB, United Kingdom.ORCID 0000-0002-1864-9700
David CabreraSchool of Pharmacy and Bioengineering, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Stoke-on-Trent ST4 7QB, United Kingdom.ORCID 0000-0001-7912-9939
Ying YangSchool of Pharmacy and Bioengineering, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Stoke-on-Trent ST4 7QB, United Kingdom.
Robert HickenDepartment of Physics and Astronomy, University of Exeter, Stocker Road, Exeter EX4 4QL, United Kingdom.
Neil TellingSchool of Pharmacy and Bioengineering, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Stoke-on-Trent ST4 7QB, United Kingdom.ORCID 0000-0002-2683-5546

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of exogenous and endogenous nanoscale magnetic material in biology is important for developing biomedical nanotechnology as well as for understanding fundamental biological processes such as iron metabolism and biomineralization. Here, we exploit the magneto-optical Faraday effect to probe intracellular magnetic properties and perform magnetic imaging, revealing the location-specific magnetization dynamics of exogenous magnetic nanoparticles within cells. The opportunities enabled by this method are shown in the context of magnetic hyperthermia; an effect where local heating is generated in magnetic nanoparticles exposed to high-frequency AC magnetic fields. Magnetic hyperthermia has the potential to be used as a cellular-level thermotherapy for cancer, as well as for other biomedical applications that target heat-sensitive cellular function. However, previous experiments have suggested that the cellular environment modifies the magnetization dynamics of nanoparticles, thus dramatically altering their heating efficiency. By combining magneto-optical and fluorescence measurements, we demonstrate a form of biological microscopy that we used here to study the magnetization dynamics of nanoparticles

Indexed as

fluorescence microscopymagnetic hyperthermiamagnetic nanoparticlesmagneto-opticsnanoscale biomaterialsnanoscale biomineralization

Identifiers

PMID38315113
PMCPMC10883041

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.