Article in Stroke, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
29 authors at 20 institutions in 1 country.
Chih-Hao ChenDepartments of Neurology (C.-H.C., S.-J.Y., S.-C.T., J.-S.J.), National Taiwan University Hospital, Taipei.ORCID 0000-0002-1258-8775
Chung-Wei LeeMedical Imaging (C.-W.L., Y.-H.L.), National Taiwan University Hospital, Taipei.ORCID 0000-0002-3573-2506
Yi-Chen HsiehProgram in Medical Neuroscience (Y.-C.H.), Taipei Medical University, Taiwan.
Chun-Jen LinDepartment of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taiwan (C.-J.L., I.-H.L).ORCID 0000-0002-5965-096X
Yu-Wei ChenDepartment of Neurology, Landseed International Hospital, Taoyuan, Taiwan (Y.-W.C.).
Kuan-Hung LinDepartment of Neurology, Chi Mei Medical Center, Tainan, Taiwan (K.-H.L.).ORCID 0000-0002-1559-3123
Pi-Shan SungDepartment of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan (P.-S.S.).ORCID 0000-0003-2505-7583
Chih-Wei TangDepartment of Neurology, Far Eastern Memorial Hospital, New Taipei City, Taiwan (C.-W.T.).ORCID 0000-0001-7577-3380
Hai-Jui ChuDepartment of Neurology, En Chu Kong Hospital, New Taipei City, Taiwan (H.-J.C.).ORCID 0000-0002-2908-7184
Kun-Chang TsaiDepartment of Neurology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu City (K.-C.T.).ORCID 0000-0001-7995-7793
Chao-Liang ChouDepartment of Neurology, Mackay Memorial Hospital, Taipei, Taiwan (C.-L.C.).
Ching-Huang LinDepartment of Neurology, Kaohsiung Veterans General Hospital, Taiwan (C.-H.L.).ORCID 0000-0001-7997-7890
Cheng-Yu WeiDepartment of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhwa County, Taiwan (C.-Y.W.).ORCID 0000-0001-9567-9877
Shang-Yih YenDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (S.-Y.Y., J.-T.L.).ORCID 0000-0002-3412-7259
Po-Lin ChenDepartment of Neurology, Taichung Veterans General Hospital, Taiwan (P.-L.C.).ORCID 0000-0002-7254-0108
Hsu-Ling YehDepartment of Neurology, Shin Kong WHS Memorial Hospital, Taipei, Taiwan (H.-L.Y., L.-M.L.).ORCID 0000-0003-4325-2366
Lung ChanDepartment of Neurology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan (L.C.).ORCID 0000-0001-5795-4460
Sheng-Feng SungDivision of Neurology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan (S.-F.S.).ORCID 0000-0002-6253-8813
Meng LeeDepartment of Neurology, Chang Gung University College of Medicine, Chang Gung Memorial Hospital Chiayi Branch, Puzi, Chiayi County, Taiwan (M.L.).ORCID 0000-0002-7491-0571
Hon-Man LiuDepartment of Medical Imaging, Fu Jen Catholic University Hospital, New Taipei City, Taiwan (H.-M.L.).
Yen-Heng LinMedical Imaging (C.-W.L., Y.-H.L.), National Taiwan University Hospital, Taipei.ORCID 0000-0003-4327-7432
I-Hui LeeDepartment of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taiwan (C.-J.L., I.-H.L).ORCID 0000-0002-5344-6685
Shin-Joe YehDepartments of Neurology (C.-H.C., S.-J.Y., S.-C.T., J.-S.J.), National Taiwan University Hospital, Taipei.ORCID 0000-0003-1511-6295
Li-Ming LienDepartment of Neurology, Shin Kong WHS Memorial Hospital, Taipei, Taiwan (H.-L.Y., L.-M.L.).
Hung-Yi ChiouSchool of Public Health, College of Public Health, (H.-Y.C.), Taipei Medical University, Taiwan.ORCID 0000-0002-4545-9697
Jiunn-Tay LeeDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (S.-Y.Y., J.-T.L.).ORCID 0000-0001-6675-5906
Sung-Chun TangDepartments of Neurology (C.-H.C., S.-J.Y., S.-C.T., J.-S.J.), National Taiwan University Hospital, Taipei.ORCID 0000-0003-3731-5973
Jiann-Shing JengDepartments of Neurology (C.-H.C., S.-J.Y., S.-C.T., J.-S.J.), National Taiwan University Hospital, Taipei.ORCID 0000-0002-1456-3686
Taiwan Registry of Endovascular Thrombectomy for Acute Ischemic Stroke (TREAT-AIS) Investigators
National Taiwan University Hospital · TWTaichung Veterans General Hospital · TWTaipei Veterans General Hospital · TWChang Bing Show Chwan Memorial Hospital · TWNational Defense Medical Center · TWTaipei Medical University · TWKaohsiung Veterans General Hospital · TWTaipei Medical University-Shuang Ho Hospital · TWChang Gung Memorial Hospital · TWFu Jen Catholic University · TWMackay Memorial Hospital · TWJen-Ai Hospital · TWChiayi Chang Gung Memorial Hospital · TWChia-Yi Christian Hospital · TWChi Mei Medical Center · TWEn Chu Kong Hospital · TWFar Eastern Memorial Hospital · TWLandseed Hospital · TWNational Cheng Kung University Hospital · TWShin Kong WHS Memorial Hospital · TW
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
backgroundTimely intravenous thrombolysis and endovascular thrombectomy are the standard reperfusion treatments for large vessel occlusion stroke. Currently, it is unknown whether a low-dose thrombolytic agent (0.6 mg/kg alteplase) can offer similar efficacy to the standard dose (0.9 mg/kg alteplase).
methodsWe enrolled consecutive patients in the multicenter Taiwan Registry of Endovascular Thrombectomy for Acute Ischemic Stroke who had received combined thrombolysis (within 4.5 hours of onset) and thrombectomy treatment from January 2019 to April 2023. The choice of low- or standard-dose alteplase was based on the physician's discretion. The outcomes included successful reperfusion (modified Thrombolysis in Cerebral Infarction score, 2b-3), symptomatic intracerebral hemorrhage, 90-day modified Rankin Scale score, and 90-day mortality. The outcomes between the 2 groups were compared using multivariable logistic regression and inverse probability of treatment weighting-adjusted analysis.
resultsAmong the 2242 patients in the Taiwan Registry of Endovascular Thrombectomy for Acute Ischemic Stroke, 734 (33%) received intravenous alteplase. Patients in the low-dose group (n=360) were older, had more women, more atrial fibrillation, and longer onset-to-needle time compared with the standard-dose group (n=374). In comparison to low-dose alteplase, standard-dose alteplase was associated with a lower rate of successful reperfusion (81% versus 87%; adjusted odds ratio, 0.63 [95% CI, 0.40-0.98]), a numerically higher incidence of symptomatic intracerebral hemorrhage (6.7% versus 3.9%; adjusted odds ratio, 1.81 [95% CI, 0.88-3.69]), but better 90-day modified Rankin Scale score (functional independence [modified Rankin Scale score, 0-2], 47% versus 31%; adjusted odds ratio, 1.91 [95% CI, 1.28-2.86]), and a numerically lower mortality rate (9% versus 15%; adjusted odds ratio, 0.73 [95% CI, 0.43-1.25]) after adjusting for covariates. Similar results were observed in the inverse probability of treatment weighting-adjusted models. The results were consistent across predefined subgroups and age strata.
conclusionsDespite the lower rate of successful reperfusion and higher risk of symptomatic intracerebral hemorrhage with standard-dose alteplase, standard-dose alteplase was associated with a better functional outcome in patients receiving combined thrombolysis and thrombectomy.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Comparing Low- or Standard-Dose Alteplase in Endovascular Thrombectomy: Insights From a Nationwide Registry. · full record | OpenQuestion