Evidence map›Paper›PMID 38314217›Full record

ReviewCurrent health sciences journal

Mechanisms of Altered Immune Response in Skin Melanoma.

Radu-Florin Fruntealată, Matei Marius, Ianis Kevyn Stefan Boboc, Smaranda Ioana Mitran, Marius Eugen Ciurea, George-Alin Stoica

Abstract readReview
In one paragraph

Review in Current health sciences journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Research Progress in Skin Aging and Immunity.International journal of molecular sciences · 2024
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Radu-Florin FruntealatăPh.D. Student, University of Medicine and Pharmacy of Craiova, Romania.
Matei MariusDepartment of Histology, University of Medicine and Pharmacy of Craiova, Romania.
Ianis Kevyn Stefan BobocExperimental Research Center for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, Romania.
Smaranda Ioana MitranDepartment of Physiology, University of Medicine and Pharmacy of Craiova, Romania.
Marius Eugen CiureaDepartment of Physiology, University of Medicine and Pharmacy of Craiova, Romania.
George-Alin StoicaDepartment of Pediatric Surgery, University of Medicine and Pharmacy of Craiova, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoma, a deadly form of skin cancer, poses significant challenges to the host immune system, allowing tumor cells to evade immune surveillance and persist. This complex interplay between melanoma and the immune system involves a multitude of mechanisms that impair immune recognition and promote tumor progression. This review summarizes the intricate strategies employed by melanoma cells to evade the immune response, including defective immune recognition, immune checkpoint activation, and the role of regulatory T-cells, myeloid-derived suppressor cells, and exosomes in suppressing anti-tumor immunity. Additionally, we discuss potential therapeutic targets aimed at reversing immune evasion in melanoma, highlighting the importance of understanding these mechanisms for developing more effective immunotherapies. Improved insights into the interactions between melanoma and the immune system will aid in the development of novel treatment strategies to enhance anti-tumor immune responses and improve patient outcomes.

Indexed as

immune responseMelanomaskin cancer

Identifiers

PMID38314217
PMCPMC10832881

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.