Evidence map›Paper›PMID 38313283›Full record

ArticlebioRxiv : the preprint server for biology2025

Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development.

Adam P Caccavano, Anna Vlachos, Nadiya McLean, Sarah Kimmel, June Hoan Kim, Geoffrey Vargish, Vivek Mahadevan, Lauren Hewitt, Anthony M Rossi, Ilona Spineux and 21 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors at 5 institutions in 1 country.

Adam P CaccavanoEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0002-6819-533X
Anna VlachosEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0002-4411-9447
Nadiya McLeanEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0002-0517-243X
Sarah KimmelEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.
June Hoan KimEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0001-9078-6892
Geoffrey VargishEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0002-2873-6517
Vivek MahadevanEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0002-0805-827X
Lauren HewittEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0001-7270-7679
Anthony M RossiHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
Ilona SpineuxHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
Sherry Jingjing WuHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
Elisabetta FurlanisHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.ORCID 0000-0002-2438-7508
Min DaiHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.ORCID 0000-0001-7584-5014
Brenda Leyva GarciaHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.ORCID 0009-0004-1968-5000
Yating WangHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
Ramesh ChittajalluEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0002-9794-0052
Edra LondonEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0003-2766-749X
Xiaoqing YuanEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Steven HuntEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0003-3533-0627
Daniel AbebeEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Mark A G EldridgeNational Institute of Mental Health (NIMH), NIH, Bethesda, MD 20892, USA.ORCID 0000-0003-4292-6832
Alex C CumminsNational Institute of Mental Health (NIMH), NIH, Bethesda, MD 20892, USA.
Brendan E HinesNational Institute of Mental Health (NIMH), NIH, Bethesda, MD 20892, USA.ORCID 0000-0003-4223-8087
Anya PlotnikovaNational Institute of Mental Health (NIMH), NIH, Bethesda, MD 20892, USA.
Arya MohantyNational Institute of Mental Health (NIMH), NIH, Bethesda, MD 20892, USA.
Bruno B AverbeckNational Institute of Mental Health (NIMH), NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-3976-8565
Kareem ZaghloulNational Institute of Neurological Disorders and Stroke (NINDS) Intramural Research Program, NIH, Bethesda, MD 20892, USA.ORCID 0000-0001-8575-3578
Jordane DimidschsteinStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-6289-6891
Gord FishellHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.ORCID 0000-0002-9640-9278
Kenneth A PelkeyEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0002-9731-1336
Chris J McBainEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Cellular and Synaptic Physiology, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0002-5909-0157
National Institutes of Health · USBroad Institute · USNational Institute of Mental Health · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Institute of Neurological Disorders and Stroke · US

Funding

Systematic identification of enhancers to target the breadth of excitatory and inhibitory neuronal cell types in the cerebral cortexUF1MH130701 · NIMH · BROAD INSTITUTE, INC. · PI ARLOTTA, PAOLA, DEVERMAN, BENJAMIN E · 2022 to 2022
$10.7M
Development and validation of AAV vectors to manipulate specific neuronal subtypes and circuits involved in epilepsy and psychiatric disorders across mammalian species.UG3MH120096 · NIMH · BROAD INSTITUTE, INC. · PI DEVERMAN, BENJAMIN E, FISHELL, GORDON J · 2019 to 2021
$6.7M
A cellular atlas of the primate and human basal gangliaU01MH124602 · NIMH · BROAD INSTITUTE, INC. · PI CHEN, FEI, FISHELL, GORDON J · 2021 to 2023
$5.0M
The molecular and cellular basis of cortical interneuron divergenceR37MH071679 · NIMH · HARVARD MEDICAL SCHOOL · PI GORDON J FISHELL · 2022 to 2026
$4.1M
NIMH NIH HHS R37 MH071679NIMH NIH HHS U01 MH124602
6 · The paper itself

Abstract

Within the adult rodent hippocampus, opioids suppress inhibitory parvalbumin-expressing interneurons (PV-INs), thus disinhibiting local micro-circuits. However, it is unknown if this disinhibitory motif is conserved in other cortical regions, species, or across development. We observed that PV-IN mediated inhibition is robustly suppressed by opioids in hippocampus proper but not primary neocortex in mice and nonhuman primates, with spontaneous inhibitory tone in resected human tissue also following a consistent dichotomy. This hippocampal disinhibitory motif was established in early development when PV-INs and opioids were found to regulate early population activity. Acute opioid-mediated modulation was partially occluded with morphine pretreatment, with implications for the effects of opioids on hippocampal network activity important for learning and memory. Together, these findings demonstrate that PV-INs exhibit a divergence in opioid sensitivity across brain regions that is remarkably conserved across evolution and highlights the underappreciated role of opioids acting through immature PV-INs in shaping hippocampal development.

Identifiers

PMID38313283
PMCPMC10836073
OpenAlexW4391065719

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.