Evidence map›Paper›PMID 38313279›Full record

ArticleResearch square2024

Repeatability of 18F-FDG uptake in metastatic bone lesions of breast cancer patients and implications for accrual to clinical trials.

Mark Muzi, Lanell M Peterson, Jennifer M Specht, Daniel S Hippe, Alena Novakova-Jiresova, Jean H Lee, Brenda F Kurland, David A Mankoff, Nancy Obuchowski, Hannah M Linden and 1 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Mark MuziUniversity of Washington School of Medicine.ORCID 0000-0002-8767-191X
Lanell M PetersonUniversity of Washington Department of Radiology.
Jennifer M SpechtUniversity of Washington School of Medicine.
Daniel S HippeUniversity of Washington Department of Radiology.
Alena Novakova-JiresovaThomayer University Hospital: Fakultni Thomayerova nemocnice.
Jean H LeeUniversity of Washington Department of Radiology.
Brenda F KurlandUniversity of Washington Department of Radiology.
David A MankoffUniversity of Pennsylvania Perelman School of Medicine.
Nancy ObuchowskiCleveland Clinic Department of Quantitative Health Sciences.
Hannah M LindenUniversity of Washington School of Medicine.
Paul E KinahanUniversity of Washington Department of Radiology.
University of Washington · USCleveland Clinic · USThomayer University Hospital · CZUniversity of Pennsylvania · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Advanced PET/CT Imaging for Improving Clinical TrialsU01CA148131 · NCI · UNIVERSITY OF WASHINGTON · PI KINAHAN, PAUL E., LINDEN, HANNAH M · 2010 to 2019
$6.0M
Core Laboratory for Advanced PET and MRI image analysisR50CA211270 · NCI · UNIVERSITY OF WASHINGTON · PI Mark Muzi · 2017 to 2026
$2.6M
PET to Measure Breast Cancer Bone Metastasis ResponseR01CA124573 · NCI · UNIVERSITY OF WASHINGTON · PI SPECHT, JENNIFER MARIE · 2007 to 2011
$1.8M
NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA124573NCI NIH HHS R50 CA211270NCI NIH HHS U01 CA148131
6 · The paper itself

Abstract

backgroundStandard measures of response such as Response Evaluation Criteria in Solid Tumors are ineffective for bone lesions, often making breast cancer patients with bone-dominant metastases ineligible for clinical trials with potentially helpful therapies. In this study we prospectively evaluated the test-retest uptake variability of 2-deoxy-2-[

resultsThe mean relative difference of SUVmax in 38 bone tumors of the first cohort was 4.3%. The upper and lower asymmetric limits of the repeatability coefficient were 19.4% and -16.3%, respectively. The

conclusionsIn evaluating bone tumor response for breast cancer patients with bone-dominant metastases using

Indexed as

bone metastasesbreast cancerFDG-PETrepeatabilitytest-retest

Identifiers

PMID38313279
PMCPMC10836099
OpenAlexW4390901820

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.