Evidence map›Paper›PMID 38313184›Full record

Observational studyJournal of medicine and life2023

Acute cerebrovascular events and inflammatory markers associated with COVID-19: An observational study.

Merey Bakytzhanovna Jumagaliyeva, Dinmukhamed Nurniyazovich Ayaganov, Ibrahim Anwar Abdelazim, Samat Sagatovich Saparbayev, Nodira Miratalievna Tuychibaeva, Yergen Jumashevich Kurmambayev

Open access · diamondAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of medicine and life, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Merey Bakytzhanovna JumagaliyevaDepartment of Neurology, Psychiatry and Narcology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Dinmukhamed Nurniyazovich AyaganovDepartment of Neurology, Psychiatry and Narcology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Ibrahim Anwar AbdelazimDepartment of Obstetrics and Gynecology, Faculty of Medicine Ain Shams University, Cairo, Egypt.
Samat Sagatovich SaparbayevDepartment of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Nodira Miratalievna TuychibaevaDepartment of Neurology, Psychology and Psychotherapy, Tashkent Medical Academy, Tashkent, Uzbekistan.
Yergen Jumashevich KurmambayevDepartment of Neurology, Psychiatry and Narcology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
West Kazakhstan Marat Ospanov State Medical University · KZAin Shams University · EGTashkent Medical Academy · UZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The novel Coronavirus disease (COVID-19) is associated with an increased risk of cerebrovascular events. About 1,228 cases of severe COVID-19 were hospitalized in the West Kazakhstan Medical University Hospital, in Aktobe, Kazakhstan, 1.22% (N=15) of whom were clinically diagnosed with acute cerebrovascular events and were included in the current study. COVID-19 was diagnosed using a nasopharyngeal polymerase chain reaction (PCR) test, blood count, inflammatory markers, and chest computerized tomography. The diagnosis of acute cerebrovascular events was based on the clinical manifestation. The participants' data were reviewed to detect the prevalence of acute cerebrovascular events and the inflammatory markers associated with COVID-19 infection. The mean age of the participants was 66.9 years (±11.07), 53% (N=8) of them were male, while 47% (N=7) were female. Moreover, 13% (N=2) presented a history of cerebrovascular events, 87% (N=13) of the participants had hypertension, 47% (N=7) had coronary heart disease, 33% (N=5) had diabetes mellitus (DM), 13% (N=2) had cardiac arrhythmia, and 13% (N=2) had chronic obstructive pulmonary disease (COPD). The C-reactive protein was high in 100% (N=15) of participants, D-dimer in 87% (N=13) of them, and both the ferritin and interleukin-6 were high in 60% (N=9) of the participants. SARS-CoV-2 causes a systemic inflammatory response, and the presence of comorbidities increases the risk of acute cerebrovascular events in COVID-19-infected individuals. The elevated inflammatory markers in severely COVID-19-infected individuals support the inflammatory "cytokine storm" response theory.

Indexed as

COVID-19Diabetes MellitusHypertensionAgedComorbidityFemaleHumansMaleMiddle AgedSARS-CoV-2ACE2: Angiotensin-converting enzyme IIASA: American Stroke Associationcerebrovascular eventsCOPD: Chronic obstructive pulmonary diseaseCOVID-19COVID-19: Coronavirus disease-19CRP: C-reactive proteinCT: Computerized tomographyCVS: Cerebrovascular strokeDM: Diabetes MellitusESR: Erythrocyte sedimentation rateGCS: Glasgow coma scaleICH: Intracerebral hemorrhageICU: Intensive care unitIL-6: Interleukin-6inflammatory markersIS: Ischemic strokeLDH: Lactate dehydrogenaseMRC: Medical Research CouncilMRI: Magnetic resonance imagingNIHSS: National Institutes of Health Stroke ScalePCR: Polymerase chain reactionWKMU: West Kazakhstan Medical University

Identifiers

PMID38313184
PMCPMC10835544
OpenAlexW4394763328

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.