Evidence map›Paper›PMID 38313047›Full record

ArticleiScience2024

A pilot study on a patient with refractory headache: Personalized deep brain stimulation through stereoelectroencephalography.

Hulin Zhao, Shuhua Zhang, Yining Wang, Chuting Zhang, Zihua Gong, Mingjie Zhang, Wei Dai, Ye Ran, Wenbin Shi, Yuanyuan Dang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Hulin ZhaoDepartment of Neurosurgery, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Shuhua ZhangDepartment of Neurology, Chinese PLA General Hospital, Beijing 100853, China.
Yining WangSchool of Information and Electronics, Beijing Institute of Technology, Beijing 100081, China.
Chuting ZhangSchool of Information and Electronics, Beijing Institute of Technology, Beijing 100081, China.
Zihua GongDepartment of Neurology, Chinese PLA General Hospital, Beijing 100853, China.
Mingjie ZhangDepartment of Neurology, Chinese PLA General Hospital, Beijing 100853, China.
Wei DaiDepartment of Neurology, Chinese PLA General Hospital, Beijing 100853, China.
Ye RanDepartment of Neurology, Chinese PLA General Hospital, Beijing 100853, China.
Wenbin ShiSchool of Information and Electronics, Beijing Institute of Technology, Beijing 100081, China.
Yuanyuan DangDepartment of Neurosurgery, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Aijun LiuDepartment of Neurosurgery, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Zhengbo ZhangCenter for Artificial Intelligence in Medicine, Chinese PLA General Hospital, Beijing 100853, China.
Chien-Hung YehSchool of Information and Electronics, Beijing Institute of Technology, Beijing 100081, China.
Zhao DongDepartment of Neurology, Chinese PLA General Hospital, Beijing 100853, China.
Shengyuan YuDepartment of Neurology, Chinese PLA General Hospital, Beijing 100853, China.
Chinese PLA General Hospital · CNBeijing Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integration of stereoelectroencephalography with therapeutic deep brain stimulation (DBS) holds immense promise as a viable approach for precise treatment of refractory disorders, yet it has not been explored in the domain of headache or pain management. Here, we implanted 14 electrodes in a patient with refractory migraine and integrated clinical assessment and electrophysiological data to investigate personalized targets for refractory headache treatment. Using statistical analyses and cross-validated machine-learning models, we identified high-frequency oscillations in the right nucleus accumbens as a critical headache-related biomarker. Through a systematic bipolar stimulation approach and blinded sham-controlled survey, combined with real-time electrophysiological data, we successfully identified the left dorsal anterior cingulate cortex as the optimal target for the best potential treatment. In this pilot study, the concept of the herein-proposed data-driven approach to optimizing precise and personalized treatment strategies for DBS may create a new frontier in the field of refractory headache and even pain disorders.

Indexed as

Clinical neuroscienceCognitive neuroscienceNeurologySensory neuroscienceTechniques in neuroscience

Identifiers

PMID38313047
PMCPMC10837616
OpenAlexW4390685334

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.