ArticleMaterials today. Bio2024
Dual-functional thermosensitive hydrogel for reducing infection and enhancing bone regeneration in infected bone defects.
Article in Materials today. Bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 13 citations in OpenAlex.
- Engineering alginate hydrogels loaded with resveratrol as a dual platform for cancer therapy and wound regeneration.Discover nano · 2026Review
- Hydrogel-integrated osteogenic microtissues promote repair of infected intervertebral defects through sequential immunomodulation.Materials today. Bio · 2026Article
- A biomimetic core-shell nanofibrous dressing for temporally coordinated infection control and mitochondrial protection in diabetic wounds.Materials today. Bio · 2026Article
- Biofunctional carboxymethyl chitosan hydrogels with nano-hydroxyapatite gradients accelerate bone defect healing.iScience · 2026Article
- Injectable hydrogels for bone regeneration: from materials design to clinical translation.RSC advances · 2026Review
- A near-infrared regulated programmable multi-mode periosteum scaffold for sequential healing of infected bone defects.Bioactive materials · 2026Article
- Emerging biomaterials for osteomyelitis treatment: from material design to anti-infection and tissue regeneration.Frontiers in cell and developmental biology · 2026Review
- Hydroxyapatite-based bone repair biomaterials based on clinical heterogeneity: modification strategies, performance regulation, and personalized repair pathways.Frontiers in bioengineering and biotechnology · 2026Review
- Engineered Poly (amino acid) Hydrogel Synchronizes Sequential Infection Elimination and Osteogenic Activation for Single-stage Reconstruction of Infected Bone Defects.Theranostics · 2026Article
- [Application and progress of intelligent responsive hydrogels in articular cartilage injury repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Review
- Functional hydrogel empowering 3D printing titanium alloys.Materials today. Bio · 2025Review
- Application and progress of temperature-sensitive hydrogels in cartilage injury repair.Frontiers in bioengineering and biotechnology · 2025Review
- A 3D-printed scaffold composed of Alg/HA/SIS for the treatment of diabetic bone defects.Journal of orthopaedic translation · 2024Article
- Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect.Frontiers in bioengineering and biotechnology · 2024Review
- Stimuli-responsive hydrogels for bone tissue engineering.Biomaterials translational · 2024Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The contamination of bone defects is a serious therapeutic problem. The treatment of infected bone defects involves rigorous infection control followed by bone reconstruction. Considering these two processes, the development of biomaterials possessing antibacterial and osteogenic properties offers a promising approach for the treatment of infected bone defects. In this study, a dual-functional, thermosensitive, and injectable hydrogel composed of chitosan (CS), quaternized CS (QCS), and nano-hydroxyapatite (nHA) was designed, and the ratio of CS to QCS in the hydrogel was optimized to enhance the antibacterial efficacy of CS while reducing the cytotoxicity of QCS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.