Evidence map›Paper›PMID 38312351›Full record

ArticlemicroPublication biology2024

SARS-Cov-2 small viral RNA suppresses gene expression via complementary binding to mRNA 3' UTR.

Haley A Delcher, Jeffrey D DeMeis, Nicole Ghobar, Noel L Godang, Sierra L Knight, Shahem Y Alqudah, Kevin N Nguyen, Brianna C Watters, Glen M Borchert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in microPublication biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haley A DelcherDepartment of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL.
Jeffrey D DeMeisDepartment of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL.
Nicole GhobarDepartment of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL.
Noel L GodangDepartment of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL.
Sierra L KnightDepartment of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL.
Shahem Y AlqudahDepartment of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL.
Kevin N NguyenDepartment of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL.
Brianna C WattersDepartment of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL.
Glen M BorchertDepartment of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL.

Funding

UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
NCATS NIH HHS UL1 TR001417
6 · The paper itself

Abstract

SARS-CoV-2 (SC2) has been intensely studied since its emergence. However, the mechanisms of host immune dysregulation triggered by SC2 remain poorly understood. That said, it is well established that many prominent viral families encode microRNAs (miRNAs) or related small viral RNAs (svRNAs) capable of regulating human genes involved in immune function. Importantly, recent reports have shown that SC2 encodes its own svRNAs. In this study, we have identified 12 svRNAs expressed during SC2 infection and show that one of these svRNAs can regulate target gene expression via complementary binding to mRNA 3' untranslated regions (3'UTRs) much like human microRNAs.

Identifiers

PMID38312351
PMCPMC10835431

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.