ArticleOpen forum infectious diseases2024
Impact of Blood Culture Contamination on Antibiotic Use, Resource Utilization, and Clinical Outcomes: A Retrospective Cohort Study in Dutch and US Hospitals.
Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Efficacy of a small-volume blood culture diversion device across three wards: a 6-month retrospective review.Microbiology spectrum · 2026Article
- Clinician perspectives on blood culture practice and diagnostic stewardship in regional emergency departments.Journal of medical microbiology · 2026Article
- Derivation and validation of a new prediction score for bacteremia in the emergency department.Scientific reports · 2026Article
- Risk factors for blood culture contamination in a tertiary hospital: a one-year retrospective analysis.BMC infectious diseases · 2026Article
- Artificial intelligence for sepsis management in the emergency department.BMC infectious diseases · 2026Review
- Likelihood of Blood Culture Positivity Using SeptiCyte RAPID.Journal of clinical medicine · 2026Article
- Detection of Paraburkholderia in Clinical Specimens Associated with Use of Nonsterile Ultrasound Gel for Percutaneous Procedures - United States, Canada, and Israel, May 2023⎯April 2025.MMWR. Morbidity and mortality weekly report · 2025Article
- Standardized surveillance of blood culture contamination rates: moving toward a universal standard.Journal of clinical microbiology · 2025Article
- Impact of an antimicrobial stewardship bundle on the outcome of high-risk neutropenic patients with fever: a pre-post study.JAC-antimicrobial resistance · 2025Article
- Multicenter evaluation of blood culture contamination and blood cultures practices in US acute care hospitals: time for standardization.Journal of clinical microbiology · 2025Article
- Limited Diagnostic Value of Blood Cultures in Patients with Soft Tissue Infections Transferred to a Quaternary Care Center.Bioengineering (Basel, Switzerland) · 2025Article
- Likelihood of blood culture positivity using SeptiCyte RAPID.medRxiv : the preprint server for health sciences · 2025Article
- Efficacy and safety of three antiseptics for neonatal skin disinfection: further evidence for chlorhexidine gluconate.Pediatric research · 2025Article
- Blood Culture Use in Medical and Surgical Intensive Care Units and Wards.JAMA network open · 2025Article
- Prospective Trial of a Passive Diversion Device to Reduce Blood Culture Contamination.Open forum infectious diseases · 2025Article
- The Effect of a Care Bundle on the Rate of Blood Culture Contamination in a General Intensive Care Unit.Antibiotics (Basel, Switzerland) · 2024Article
- Early detection of bloodstream infection in critically ill children using artificial intelligence.Acute and critical care · 2024Article
- The foundation for the microbiology laboratory's essential role in diagnostic stewardship: an ASM Laboratory Practices Subcommittee report.Journal of clinical microbiology · 2024Review
- Every Crisis Is an Opportunity: Advancing Blood Culture Stewardship During a Blood Culture Bottle Shortage.Open forum infectious diseases · 2024Article
- Effectiveness of A Nurse-Led Multimodal Intervention in Preventing Blood Culture Contamination: A Before-and-After Study.Healthcare (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Background: Blood culture contamination (BCC) has been associated with prolonged antibiotic use (AU) and increased health care utilization; however, this has not been widely reevaluated in the era of increased attention to antibiotic stewardship. We evaluated the impact of BCC on AU, resource utilization, and length of stay in Dutch and US patients. Methods: This retrospective observational study examined adults admitted to 2 hospitals in the Netherlands and 5 hospitals in the United States undergoing ≥2 blood culture (BC) sets. Exclusion criteria included neutropenia, no hospital admission, or death within 48 hours of hospitalization. The impact of BCC on clinical outcomes-overall inpatient days of antibiotic therapy, test utilization, length of stay, and mortality-was determined via a multivariable regression model. Results: An overall 22 927 patient admissions were evaluated: 650 (4.1%) and 339 (4.8%) with BCC and 11 437 (71.8%) and 4648 (66.3%) with negative BC results from the Netherlands and the United States, respectively. Dutch and US patients with BCC had a mean ± SE 1.74 ± 0.27 ( Conclusions: BCC remains associated with higher inpatient AU and health care utilization as compared with patients with negative BC results, although the impact on these outcomes differs by country.
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